PTPN1

GENERAL INFORMATION

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Gene name

PTPN1

Gene description

Protein tyrosine phosphatase, non-receptor type 1

Protein class

Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in many tissues with lowest levels in CNS and highest levels in lymphoid tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA012542 , CAB009329 , CAB015217
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PTPN1 (HGNC Symbol)

Synonyms

PTP1B

Description

Protein tyrosine phosphatase, non-receptor type 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

Chromosome

20

Cytoband

q13.13

Chromosome location (bp)

50510321 - 50585241

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196396 (version 78.38)

Entrez gene

5770

UniProt

P18031 (UniProt - Evidence at protein level)

neXtProt

NX_P18031

Antibodypedia

PTPN1 antibodies


PROTEIN BROWSER

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ENST00000371621
 
ENST00000541713
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPN1-001 ENSP00000360683
ENST00000371621
P18031
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Show » Show » 435 50 No 1
PTPN1-201 ENSP00000437732
ENST00000541713
B4DSN5
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Show » Show » 362 41.3 No 1