AGRN

GENERAL INFORMATION

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Gene name

AGRN

Gene description

Agrin

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed weak to moderate cytoplasmic positivity. Adrenocrtical cells, neuronal cells of cerebral cortex, gall bladder, renal tubules, hepatocytes, duodenum and ducts in salivary gland were strongly stained. Pneumocytes, pancreas, renal glomeruli and prostate were mainly negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA040090
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

AGRN (HGNC Symbol)

Synonyms

AGRIN

Description

Agrin (HGNC Symbol)

Entrez gene summary

This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. [provided by RefSeq, Aug 2011]

Chromosome

1

Cytoband

p36.33

Chromosome location (bp)

1020123 - 1056118

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000188157 (version 78.38)

Entrez gene

375790

UniProt

O00468 (UniProt - Evidence at protein level)

neXtProt

NX_O00468

Antibodypedia

AGRN antibodies


PROTEIN BROWSER

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ENST00000379370
 
ENST00000419249
 
ENST00000620552
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AGRN-001 ENSP00000368678
ENST00000379370
O00468
Show all »
Show » Show » 2045 214.8 Yes 0
AGRN-009 ENSP00000400771
ENST00000419249
Show » Show » 271 28.7 No 0
AGRN-201 ENSP00000484607
ENST00000620552
Q5XG79
Show all »
Show » Show » 1930 202.3 No 0