PPARA

GENERAL INFORMATION

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Gene name

PPARA

Gene description

Peroxisome proliferator-activated receptor alpha

Protein class

FDA approved drug targets
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PPARA (HGNC Symbol)

Synonyms

hPPAR, NR1C1, PPAR

Description

Peroxisome proliferator-activated receptor alpha (HGNC Symbol)

Entrez gene summary

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q13.31

Chromosome location (bp)

46150521 - 46243756

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000186951 (version 78.38)

Entrez gene

5465

UniProt

Q07869 (UniProt - Evidence at protein level)

neXtProt

NX_Q07869

Antibodypedia

PPARA antibodies


PROTEIN BROWSER

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ENST00000262735
 
ENST00000402126
 
ENST00000407236
 
ENST00000415785
 
ENST00000420804
 
ENST00000440343
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PPARA-001 ENSP00000385523
ENST00000407236
Q07869
Show all »
Show » Show » 468 52.2 No 0
PPARA-002 ENSP00000397291
ENST00000440343
Show » 9 1 No 0
PPARA-003 ENSP00000414752
ENST00000420804
B0QYX1
Show all »
Show » Show » 133 14.1 No 0
PPARA-008 ENSP00000385246
ENST00000402126
Q07869
Show all »
Show » Show » 468 52.2 No 0
PPARA-009 ENSP00000411677
ENST00000415785
B0QYX2
Show all »
Show » Show » 69 7.3 No 0
PPARA-201 ENSP00000262735
ENST00000262735
Q07869
Show all »
Show » Show » 468 52.2 No 0