Tissue expression of SCN5A - Summary - The Human Protein Atlas

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SCN5A

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS

GENE/PROTEIN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	SCN5A
Gene description	Sodium channel, voltage-gated, type V, alpha subunit
Protein class	Disease related genes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Tissue enriched (heart muscle)
GTEx:	Group enriched (heart muscle)

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability	Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW ? »
Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation. For genes with available protein data for which a knowledge-based annotation could not be performed, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Tissue enriched (heart muscle)

Organ

Expression

GTEx dataset

RNA tissue category:

Group enriched (heart muscle)

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	SCN5A (HGNC Symbol)
Synonyms	CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1
Description	Sodium channel, voltage-gated, type V, alpha subunit (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	38548057 - 38649673
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183873 (version 78.38)
Entrez gene	6331
UniProt	Q14524 (UniProt - Evidence at protein level)
neXtProt	NX_Q14524
Antibodypedia	SCN5A antibodies

PROTEIN BROWSER

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ENST00000327956		ENST00000333535		ENST00000413689		ENST00000414099		ENST00000423572		ENST00000425664		ENST00000443581		ENST00000449557		ENST00000450102		ENST00000451551		ENST00000455624		ENST00000612060

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
SCN5A-001	ENSP00000410257 ENST00000413689	H9KVD2 Show all » « Hide H9KVD2 [Target identity:100%; Query identity:100%] Sodium channel protein {ECO:0000256\|RuleBase:RU361132} Q8WTS0 [Target identity:7%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84529.1} A3EY20 [Target identity:6%; Query identity:100%] Cardiac sodium channel alpha subunit variant {ECO:0000313\|EMBL:ABN50063.1} A3EY21 [Target identity:3%; Query identity:100%] Cardiac sodium channel alpha subunit {ECO:0000313\|EMBL:ABN50064.1}; Sodium channel protein type 5 subunit alpha {ECO:0000313\|Ensembl:ENSP00000333674} Q8WWN5 [Target identity:3%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84536.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0001518 [voltage-gated sodium channel complex] GO:0003231 [cardiac ventricle development] GO:0005216 [ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0009986 [cell surface] GO:0014070 [response to organic cyclic compound] GO:0014704 [intercalated disc] GO:0016020 [membrane] GO:0030315 [T-tubule] GO:0034706 [sodium channel complex] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0086004 [regulation of cardiac muscle cell contraction] GO:0086006 [voltage-gated sodium channel activity involved in cardiac muscle cell action potential] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086046 [membrane depolarization during SA node cell action potential] GO:0086063 [voltage-gated sodium channel activity involved in SA node cell action potential] GO:0086091 [regulation of heart rate by cardiac conduction] GO:0097110 [scaffold protein binding]	2016	226.9	No	>9
SCN5A-002	ENSP00000399524 ENST00000455624	E9PHB6 Show all » « Hide E9PHB6 [Target identity:100%; Query identity:100%] Sodium channel protein {ECO:0000256\|RuleBase:RU361132} Q8WTS0 [Target identity:7%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84529.1} A3EY21 [Target identity:3%; Query identity:100%] Cardiac sodium channel alpha subunit {ECO:0000313\|EMBL:ABN50064.1}; Sodium channel protein type 5 subunit alpha {ECO:0000313\|Ensembl:ENSP00000333674} Q8WWN5 [Target identity:3%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84536.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0001518 [voltage-gated sodium channel complex] GO:0005216 [ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport]	1983	223.1	No	>9
SCN5A-003	ENSP00000398266 ENST00000423572	Q14524 Show all » « Hide Q14524 [Direct mapping] Sodium channel protein type 5 subunit alpha Q8WTQ6 [Target identity:7%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84533.1} A3EY20 [Target identity:6%; Query identity:100%] Cardiac sodium channel alpha subunit variant {ECO:0000313\|EMBL:ABN50063.1} A3EY21 [Target identity:3%; Query identity:100%] Cardiac sodium channel alpha subunit {ECO:0000313\|EMBL:ABN50064.1}; Sodium channel protein type 5 subunit alpha {ECO:0000313\|Ensembl:ENSP00000333674} Q8WWN5 [Target identity:3%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84536.1}	Show » « Hide Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Sodium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0001518 [voltage-gated sodium channel complex] GO:0002027 [regulation of heart rate] GO:0003231 [cardiac ventricle development] GO:0003360 [brainstem development] GO:0005216 [ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0009986 [cell surface] GO:0010765 [positive regulation of sodium ion transport] GO:0014704 [intercalated disc] GO:0014894 [response to denervation involved in regulation of muscle adaptation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016328 [lateral plasma membrane] GO:0017134 [fibroblast growth factor binding] GO:0019228 [neuronal action potential] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0021537 [telencephalon development] GO:0021549 [cerebellum development] GO:0030315 [T-tubule] GO:0030506 [ankyrin binding] GO:0031625 [ubiquitin protein ligase binding] GO:0035725 [sodium ion transmembrane transport] GO:0042383 [sarcolemma] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0044325 [ion channel binding] GO:0045760 [positive regulation of action potential] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050998 [nitric-oxide synthase binding] GO:0051899 [membrane depolarization] GO:0055085 [transmembrane transport] GO:0060048 [cardiac muscle contraction] GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization] GO:0060371 [regulation of atrial cardiac muscle cell membrane depolarization] GO:0060372 [regulation of atrial cardiac muscle cell membrane repolarization] GO:0060373 [regulation of ventricular cardiac muscle cell membrane depolarization] GO:0071277 [cellular response to calcium ion] GO:0086002 [cardiac muscle cell action potential involved in contraction] GO:0086004 [regulation of cardiac muscle cell contraction] GO:0086005 [ventricular cardiac muscle cell action potential] GO:0086006 [voltage-gated sodium channel activity involved in cardiac muscle cell action potential] GO:0086010 [membrane depolarization during action potential] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086046 [membrane depolarization during SA node cell action potential] GO:0086067 [AV node cell to bundle of His cell communication] GO:0086069 [bundle of His cell to Purkinje myocyte communication] GO:0086070 [SA node cell to atrial cardiac muscle cell communication] GO:0086091 [regulation of heart rate by cardiac conduction] GO:0097110 [scaffold protein binding] GO:1902305 [regulation of sodium ion transmembrane transport]	2015	226.8	No	>9
SCN5A-004	ENSP00000398962 ENST00000414099	E9PG18 Show all » « Hide E9PG18 [Target identity:100%; Query identity:100%] Sodium channel protein {ECO:0000256\|RuleBase:RU361132} Q8WTS0 [Target identity:7%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84529.1} A3EY20 [Target identity:6%; Query identity:100%] Cardiac sodium channel alpha subunit variant {ECO:0000313\|EMBL:ABN50063.1} A3EY21 [Target identity:3%; Query identity:100%] Cardiac sodium channel alpha subunit {ECO:0000313\|EMBL:ABN50064.1}; Sodium channel protein type 5 subunit alpha {ECO:0000313\|Ensembl:ENSP00000333674} Q8WWN5 [Target identity:3%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84536.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0001518 [voltage-gated sodium channel complex] GO:0005216 [ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport]	1998	224.9	No	>9
SCN5A-006	ENSP00000333674 ENST00000327956	A3EY21 Show all » « Hide A3EY21 [Target identity:100%; Query identity:100%] Cardiac sodium channel alpha subunit {ECO:0000313\|EMBL:ABN50064.1}; Sodium channel protein type 5 subunit alpha {ECO:0000313\|Ensembl:ENSP00000333674}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)		65	7.4	No	0
SCN5A-008	ENSP00000403355 ENST00000450102	K4DIA1 Show all » « Hide K4DIA1 [Target identity:100%; Query identity:100%] Sodium channel protein {ECO:0000256\|RuleBase:RU361132} Q8WTS0 [Target identity:7%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84529.1} A3EY20 [Target identity:6%; Query identity:100%] Cardiac sodium channel alpha subunit variant {ECO:0000313\|EMBL:ABN50063.1} A3EY21 [Target identity:3%; Query identity:100%] Cardiac sodium channel alpha subunit {ECO:0000313\|EMBL:ABN50064.1}; Sodium channel protein type 5 subunit alpha {ECO:0000313\|Ensembl:ENSP00000333674} Q8WWN5 [Target identity:3%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84536.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0001518 [voltage-gated sodium channel complex] GO:0005216 [ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport]	1962	221.3	No	>9
SCN5A-010	ENSP00000413996 ENST00000449557	Q8WTQ6 Show all » « Hide Q8WTQ6 [Target identity:7%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84533.1} A3EY20 [Target identity:6%; Query identity:100%] Cardiac sodium channel alpha subunit variant {ECO:0000313\|EMBL:ABN50063.1} A3EY21 [Target identity:3%; Query identity:100%] Cardiac sodium channel alpha subunit {ECO:0000313\|EMBL:ABN50064.1}; Sodium channel protein type 5 subunit alpha {ECO:0000313\|Ensembl:ENSP00000333674} Q8WWN5 [Target identity:3%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84536.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0001518 [voltage-gated sodium channel complex] GO:0005216 [ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0055085 [transmembrane transport]	1962	221.3	No	>9
SCN5A-014	ENSP00000328968 ENST00000333535	Q14524 Show all » « Hide Q14524 [Direct mapping] Sodium channel protein type 5 subunit alpha Q8WTQ6 [Target identity:7%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84533.1} A3EY20 [Target identity:6%; Query identity:100%] Cardiac sodium channel alpha subunit variant {ECO:0000313\|EMBL:ABN50063.1} A3EY21 [Target identity:3%; Query identity:100%] Cardiac sodium channel alpha subunit {ECO:0000313\|EMBL:ABN50064.1}; Sodium channel protein type 5 subunit alpha {ECO:0000313\|Ensembl:ENSP00000333674} Q8WWN5 [Target identity:3%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84536.1}	Show » « Hide Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Sodium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0001518 [voltage-gated sodium channel complex] GO:0002027 [regulation of heart rate] GO:0003231 [cardiac ventricle development] GO:0003360 [brainstem development] GO:0005216 [ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0009986 [cell surface] GO:0010765 [positive regulation of sodium ion transport] GO:0014704 [intercalated disc] GO:0014894 [response to denervation involved in regulation of muscle adaptation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016328 [lateral plasma membrane] GO:0017134 [fibroblast growth factor binding] GO:0019228 [neuronal action potential] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0021537 [telencephalon development] GO:0021549 [cerebellum development] GO:0030315 [T-tubule] GO:0030506 [ankyrin binding] GO:0031625 [ubiquitin protein ligase binding] GO:0035725 [sodium ion transmembrane transport] GO:0042383 [sarcolemma] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0044325 [ion channel binding] GO:0045760 [positive regulation of action potential] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050998 [nitric-oxide synthase binding] GO:0051899 [membrane depolarization] GO:0055085 [transmembrane transport] GO:0060048 [cardiac muscle contraction] GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization] GO:0060371 [regulation of atrial cardiac muscle cell membrane depolarization] GO:0060372 [regulation of atrial cardiac muscle cell membrane repolarization] GO:0060373 [regulation of ventricular cardiac muscle cell membrane depolarization] GO:0071277 [cellular response to calcium ion] GO:0086002 [cardiac muscle cell action potential involved in contraction] GO:0086004 [regulation of cardiac muscle cell contraction] GO:0086005 [ventricular cardiac muscle cell action potential] GO:0086006 [voltage-gated sodium channel activity involved in cardiac muscle cell action potential] GO:0086010 [membrane depolarization during action potential] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086046 [membrane depolarization during SA node cell action potential] GO:0086067 [AV node cell to bundle of His cell communication] GO:0086069 [bundle of His cell to Purkinje myocyte communication] GO:0086070 [SA node cell to atrial cardiac muscle cell communication] GO:0086091 [regulation of heart rate by cardiac conduction] GO:0097110 [scaffold protein binding] GO:1902305 [regulation of sodium ion transmembrane transport]	2016	226.9	No	>9
SCN5A-201	ENSP00000416634 ENST00000425664	E9PG18 Show all » « Hide E9PG18 [Target identity:100%; Query identity:100%] Sodium channel protein {ECO:0000256\|RuleBase:RU361132} Q8WTS0 [Target identity:7%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84529.1} A3EY20 [Target identity:6%; Query identity:100%] Cardiac sodium channel alpha subunit variant {ECO:0000313\|EMBL:ABN50063.1} A3EY21 [Target identity:3%; Query identity:100%] Cardiac sodium channel alpha subunit {ECO:0000313\|EMBL:ABN50064.1}; Sodium channel protein type 5 subunit alpha {ECO:0000313\|Ensembl:ENSP00000333674} Q8WWN5 [Target identity:3%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84536.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0001518 [voltage-gated sodium channel complex] GO:0005216 [ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport]	1998	224.9	No	>9
SCN5A-202	ENSP00000397915 ENST00000443581	Q14524 Show all » « Hide Q14524 [Direct mapping] Sodium channel protein type 5 subunit alpha Q8WTQ6 [Target identity:7%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84533.1} A3EY20 [Target identity:6%; Query identity:100%] Cardiac sodium channel alpha subunit variant {ECO:0000313\|EMBL:ABN50063.1} A3EY21 [Target identity:3%; Query identity:100%] Cardiac sodium channel alpha subunit {ECO:0000313\|EMBL:ABN50064.1}; Sodium channel protein type 5 subunit alpha {ECO:0000313\|Ensembl:ENSP00000333674} Q8WWN5 [Target identity:3%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84536.1}	Show » « Hide Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Sodium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0001518 [voltage-gated sodium channel complex] GO:0002027 [regulation of heart rate] GO:0003231 [cardiac ventricle development] GO:0003360 [brainstem development] GO:0005216 [ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0009986 [cell surface] GO:0010765 [positive regulation of sodium ion transport] GO:0014704 [intercalated disc] GO:0014894 [response to denervation involved in regulation of muscle adaptation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016328 [lateral plasma membrane] GO:0017134 [fibroblast growth factor binding] GO:0019228 [neuronal action potential] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0021537 [telencephalon development] GO:0021549 [cerebellum development] GO:0030315 [T-tubule] GO:0030506 [ankyrin binding] GO:0031625 [ubiquitin protein ligase binding] GO:0035725 [sodium ion transmembrane transport] GO:0042383 [sarcolemma] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0044325 [ion channel binding] GO:0045760 [positive regulation of action potential] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050998 [nitric-oxide synthase binding] GO:0051899 [membrane depolarization] GO:0055085 [transmembrane transport] GO:0060048 [cardiac muscle contraction] GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization] GO:0060371 [regulation of atrial cardiac muscle cell membrane depolarization] GO:0060372 [regulation of atrial cardiac muscle cell membrane repolarization] GO:0060373 [regulation of ventricular cardiac muscle cell membrane depolarization] GO:0071277 [cellular response to calcium ion] GO:0086002 [cardiac muscle cell action potential involved in contraction] GO:0086004 [regulation of cardiac muscle cell contraction] GO:0086005 [ventricular cardiac muscle cell action potential] GO:0086006 [voltage-gated sodium channel activity involved in cardiac muscle cell action potential] GO:0086010 [membrane depolarization during action potential] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086046 [membrane depolarization during SA node cell action potential] GO:0086067 [AV node cell to bundle of His cell communication] GO:0086069 [bundle of His cell to Purkinje myocyte communication] GO:0086070 [SA node cell to atrial cardiac muscle cell communication] GO:0086091 [regulation of heart rate by cardiac conduction] GO:0097110 [scaffold protein binding] GO:1902305 [regulation of sodium ion transmembrane transport]	2016	226.9	No	>9
SCN5A-203	ENSP00000388797 ENST00000451551	K4DIA1 Show all » « Hide K4DIA1 [Target identity:100%; Query identity:100%] Sodium channel protein {ECO:0000256\|RuleBase:RU361132} Q8WTS0 [Target identity:7%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84529.1} A3EY20 [Target identity:6%; Query identity:100%] Cardiac sodium channel alpha subunit variant {ECO:0000313\|EMBL:ABN50063.1} A3EY21 [Target identity:3%; Query identity:100%] Cardiac sodium channel alpha subunit {ECO:0000313\|EMBL:ABN50064.1}; Sodium channel protein type 5 subunit alpha {ECO:0000313\|Ensembl:ENSP00000333674} Q8WWN5 [Target identity:3%; Query identity:100%] Nav1.5 {ECO:0000313\|EMBL:CAC84536.1}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0001518 [voltage-gated sodium channel complex] GO:0005216 [ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport]	1962	221.3	No	>9
SCN5A-204	ENSP00000479016 ENST00000612060	Q86V90 Show all » « Hide Q86V90 [Target identity:100%; Query identity:100%] SCN5A protein {ECO:0000313\|EMBL:AAH51374.1} A3EY21 [Target identity:29%; Query identity:100%] Cardiac sodium channel alpha subunit {ECO:0000313\|EMBL:ABN50064.1}; Sodium channel protein type 5 subunit alpha {ECO:0000313\|Ensembl:ENSP00000333674}	Show » « Hide Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014)	Show » « Hide GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0055085 [transmembrane transport]	223	25.4	No	3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx