ADIPOQ

GENERAL INFORMATION

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Gene name

ADIPOQ

Gene description

Adiponectin, C1Q and collagen domain containing

Protein class

Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (adipose tissue)
GTEx:Group enriched (adipose tissue, breast)

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic and membranous expression in adipocytes, endothelial cells, muscle cells and basal cells of squamous epithelia.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External characterization data supports antibody staining.

Data reliability

Supportive based on 2 antibodies.
HPA051767 , CAB046467
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Soft tissue



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (adipose tissue)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (adipose tissue, breast)

Organ

Expression



GENE INFORMATION

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Gene name

ADIPOQ (HGNC Symbol)

Synonyms

ACDC, ACRP30, adiponectin, AdipoQ, apM1, GBP28

Description

Adiponectin, C1Q and collagen domain containing (HGNC Symbol)

Entrez gene summary

This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]

Chromosome

3

Cytoband

q27.3

Chromosome location (bp)

186842690 - 186858463

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000181092 (version 78.38)

Entrez gene

9370

UniProt

Q15848 (UniProt - Evidence at protein level)

neXtProt

NX_Q15848

Antibodypedia

ADIPOQ antibodies


PROTEIN BROWSER

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ENST00000320741
 
ENST00000444204
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADIPOQ-001 ENSP00000389814
ENST00000444204
Q15848
Show all »
Show » Show » 244 26.4 Yes 0
ADIPOQ-002 ENSP00000320709
ENST00000320741
Q15848
Show all »
Show » Show » 244 26.4 Yes 0