F2

GENERAL INFORMATION

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Gene name

F2

Gene description

Coagulation factor II (thrombin)

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein localization

Distinct expression in a subset of hepatocytes and positivity in plasma.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Data reliability

Supportive based on 4 antibodies.
HPA051476 , HPA054698 , CAB016780 , CAB018650
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression



GENE INFORMATION

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Gene name

F2

Synonyms

Description

Coagulation factor II (thrombin) (HGNC Symbol)

Entrez gene summary

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Finally, peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Nov 2014]

Chromosome

11

Cytoband

p11.2

Chromosome location (bp)

46719180 - 46739506

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000180210 (version 78.38)

Entrez gene

2147

UniProt

P00734 (UniProt - Evidence at protein level)

neXtProt

NX_P00734

Antibodypedia

F2 antibodies


PROTEIN BROWSER

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ENST00000311907
 
ENST00000442468
 
ENST00000530231
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F2-001 ENSP00000308541
ENST00000311907
P00734
Show all »
Show » Show » 622 70 Yes 0
F2-003 ENSP00000387413
ENST00000442468
C9JV37
Show all »
Show » Show » 324 35.9 No 0
F2-005 ENSP00000433907
ENST00000530231
E9PIT3
Show all »
Show » Show » 583 65.4 Yes 0