ALOX15B - Gene info - The Human Protein Atlas

Gene name

ALOX15B (HGNC Symbol)

Synonyms

15-LOX-2

Description

Arachidonate 15-lipoxygenase, type B (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

p13.1

Chromosome location (bp)

8039017 - 8049134

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000179593 (version 78.38)

Entrez gene

247

UniProt

O15296 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALOX15B-001

ENSP00000369530
ENST00000380183

O15296
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O15296 [Direct mapping]
Arachidonate 15-lipoxygenase B

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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cytoskeleton related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005506 [iron ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006915 [apoptotic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0016020 [membrane]
GO:0016165 [linoleate 13S-lipoxygenase activity]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0019369 [arachidonic acid metabolic process]
GO:0019372 [lipoxygenase pathway]
GO:0019898 [extrinsic component of membrane]
GO:0030336 [negative regulation of cell migration]
GO:0030850 [prostate gland development]
GO:0030856 [regulation of epithelial cell differentiation]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0036403 [arachidonate 8(S)-lipoxygenase activity]
GO:0043651 [linoleic acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045618 [positive regulation of keratinocyte differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045926 [negative regulation of growth]
GO:0046872 [metal ion binding]
GO:0050473 [arachidonate 15-lipoxygenase activity]
GO:0051122 [hepoxilin biosynthetic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular vesicular exosome]
GO:0090197 [positive regulation of chemokine secretion]

676

75.9

ALOX15B-002

ENSP00000458749
ENST00000572022

I3L1D5
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I3L1D5 [Target identity:100%; Query identity:100%]
Arachidonate 15-lipoxygenase B {ECO:0000313|Ensembl:ENSP00000458749}

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SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]

664

74.5

ALOX15B-005

ENSP00000460332
ENST00000573359

O15296
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O15296 [Direct mapping]
Arachidonate 15-lipoxygenase B

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GO:0005506 [iron ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006915 [apoptotic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0016020 [membrane]
GO:0016165 [linoleate 13S-lipoxygenase activity]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0019369 [arachidonic acid metabolic process]
GO:0019372 [lipoxygenase pathway]
GO:0019898 [extrinsic component of membrane]
GO:0030336 [negative regulation of cell migration]
GO:0030850 [prostate gland development]
GO:0030856 [regulation of epithelial cell differentiation]
GO:0044281 [small molecule metabolic process]
GO:0045786 [negative regulation of cell cycle]
GO:0045926 [negative regulation of growth]
GO:0046872 [metal ion binding]
GO:0050473 [arachidonate 15-lipoxygenase activity]
GO:0051122 [hepoxilin biosynthetic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular vesicular exosome]
GO:0090197 [positive regulation of chemokine secretion]

602

67.3

ALOX15B-201

ENSP00000369520
ENST00000380173

O15296
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O15296 [Direct mapping]
Arachidonate 15-lipoxygenase B

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GO:0005506 [iron ion binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006915 [apoptotic process]
GO:0008285 [negative regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0016020 [membrane]
GO:0016165 [linoleate 13S-lipoxygenase activity]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0019369 [arachidonic acid metabolic process]
GO:0019372 [lipoxygenase pathway]
GO:0019898 [extrinsic component of membrane]
GO:0030336 [negative regulation of cell migration]
GO:0030850 [prostate gland development]
GO:0030856 [regulation of epithelial cell differentiation]
GO:0044281 [small molecule metabolic process]
GO:0045786 [negative regulation of cell cycle]
GO:0045926 [negative regulation of growth]
GO:0046872 [metal ion binding]
GO:0050473 [arachidonate 15-lipoxygenase activity]
GO:0051122 [hepoxilin biosynthetic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular vesicular exosome]
GO:0090197 [positive regulation of chemokine secretion]

647

72.5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.