CIITA

GENE INFORMATION

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Gene name

CIITA (HGNC Symbol)

Synonyms

C2TA, MHC2TA, NLRA

Description

Class II, major histocompatibility complex, transactivator (HGNC Symbol)

Entrez gene summary

This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the ""master control factor"" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Chromosome

16

Cytoband

p13.13

Chromosome location (bp)

10877198 - 10932281

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000179583 (version 78.38)

Entrez gene

4261

UniProt

P33076 (UniProt - Evidence at protein level)

neXtProt

NX_P33076

Antibodypedia

CIITA antibodies
 

PROTEIN VIEW

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CIITA-001
 
CIITA-002
 
CIITA-008
 
CIITA-201
 
CIITA-202
 
CIITA-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CIITA-001 ENSP00000316328
ENST00000324288
Show » 1130 123.4 No 0
CIITA-002 ENSP00000371257
ENST00000381835
P33076
Show all »
Show » Show » 546 59.6 No 0
CIITA-008 ENSP00000459608
ENST00000576601
Show » 177 19.7 No 0
CIITA-201 ENSP00000483487
ENST00000611587
Show » 884 96.5 No 0
CIITA-202 ENSP00000484761
ENST00000618207
Q29704
Show all »
Show » 353 38.2 No 0
CIITA-203 ENSP00000485010
ENST00000618327
Show » Show » 1131 123.5 No 0