ALOXE3

GENE INFORMATION

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Gene name

ALOXE3 (HGNC Symbol)

Synonyms

E-LOX, eLOX3

Description

Arachidonate lipoxygenase 3 (HGNC Symbol)

Entrez gene summary

This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Chromosome

17

Cytoband

p13.1

Chromosome location (bp)

8095900 - 8119047

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000179148 (version 78.38)

Entrez gene

59344

UniProt

Q9BYJ1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BYJ1

Antibodypedia

ALOXE3 antibodies
 

PROTEIN VIEW

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ALOXE3-001
 
ALOXE3-002
 
ALOXE3-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALOXE3-001 ENSP00000369494
ENST00000380149
J3KPH2
Show all »
Show » Show » 867 97.8 No 0
ALOXE3-002 ENSP00000314879
ENST00000318227
Q9BYJ1
Show all »
Show » Show » 843 95.2 No 0
ALOXE3-003 ENSP00000400581
ENST00000448843
Q9BYJ1
Show all »
Show » Show » 711 80.5 No 0