Tissue expression of GRB2 - Summary - The Human Protein Atlas

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GRB2

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	GRB2
Gene description	Growth factor receptor-bound protein 2
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and nuclear immunoreactivity of moderate intensity was observed in most normal tissues. Strongest staining was observed in lymphoid tissues.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Uncertain based on 1 antibody. CAB002589
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	GRB2 (HGNC Symbol)
Synonyms	NCKAP2
Description	Growth factor receptor-bound protein 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q25.1
Chromosome location (bp)	75318076 - 75405709
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177885 (version 78.38)
Entrez gene	2885
UniProt	P62993 (UniProt - Evidence at protein level)
neXtProt	NX_P62993
Antibodypedia	GRB2 antibodies

PROTEIN BROWSER

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ENST00000316615		ENST00000316804		ENST00000392562		ENST00000392563		ENST00000392564		ENST00000578961		ENST00000581959		ENST00000582582

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
GRB2-001	ENSP00000339007 ENST00000316804	P62993 Show all » « Hide P62993 [Direct mapping] Growth factor receptor-bound protein 2 B0LPF3 [Target identity:100%; Query identity:100%] Growth factor receptor-bound protein 2 {ECO:0000313\|EMBL:ABY87532.1}; Growth factor receptor-bound protein 2, isoform CRA_a {ECO:0000313\|EMBL:EAW89270.1}; cDNA, FLJ96637, Homo sapiens growth factor receptor-bound protein 2 (GRB2), mRNA {ECO:0000313\|EMBL:BAG37940.1} J3KT38 [Target identity:50%; Query identity:100%] Growth factor receptor-bound protein 2 {ECO:0000313\|Ensembl:ENSP00000462785}	Show » « Hide Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005070 [SH3/SH2 adaptor activity] GO:0005154 [epidermal growth factor receptor binding] GO:0005168 [neurotrophin TRKA receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007265 [Ras protein signal transduction] GO:0007267 [cell-cell signaling] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008180 [COP9 signalosome] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016032 [viral process] GO:0017124 [SH3 domain binding] GO:0019901 [protein kinase binding] GO:0030168 [platelet activation] GO:0031295 [T cell costimulation] GO:0031623 [receptor internalization] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0043560 [insulin receptor substrate binding] GO:0044822 [poly(A) RNA binding] GO:0045087 [innate immune response] GO:0046875 [ephrin receptor binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050900 [leukocyte migration] GO:0070062 [extracellular vesicular exosome] GO:0070436 [Grb2-EGFR complex] GO:0071479 [cellular response to ionizing radiation] GO:2000379 [positive regulation of reactive oxygen species metabolic process]	217	25.2	No
GRB2-002	ENSP00000376345 ENST00000392562	P62993 Show all » « Hide P62993 [Direct mapping] Growth factor receptor-bound protein 2 B0LPF3 [Target identity:100%; Query identity:100%] Growth factor receptor-bound protein 2 {ECO:0000313\|EMBL:ABY87532.1}; Growth factor receptor-bound protein 2, isoform CRA_a {ECO:0000313\|EMBL:EAW89270.1}; cDNA, FLJ96637, Homo sapiens growth factor receptor-bound protein 2 (GRB2), mRNA {ECO:0000313\|EMBL:BAG37940.1} J3KT38 [Target identity:50%; Query identity:100%] Growth factor receptor-bound protein 2 {ECO:0000313\|Ensembl:ENSP00000462785}	Show » « Hide Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001784 [phosphotyrosine binding] GO:0005070 [SH3/SH2 adaptor activity] GO:0005154 [epidermal growth factor receptor binding] GO:0005168 [neurotrophin TRKA receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007265 [Ras protein signal transduction] GO:0007267 [cell-cell signaling] GO:0007411 [axon guidance] GO:0007568 [aging] GO:0007596 [blood coagulation] GO:0008180 [COP9 signalosome] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009967 [positive regulation of signal transduction] GO:0012506 [vesicle membrane] GO:0016020 [membrane] GO:0016032 [viral process] GO:0017124 [SH3 domain binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0019904 [protein domain specific binding] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030838 [positive regulation of actin filament polymerization] GO:0031295 [T cell costimulation] GO:0031623 [receptor internalization] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0043234 [protein complex] GO:0043408 [regulation of MAPK cascade] GO:0043560 [insulin receptor substrate binding] GO:0044822 [poly(A) RNA binding] GO:0045087 [innate immune response] GO:0046875 [ephrin receptor binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048646 [anatomical structure formation involved in morphogenesis] GO:0050900 [leukocyte migration] GO:0051219 [phosphoprotein binding] GO:0051291 [protein heterooligomerization] GO:0060670 [branching involved in labyrinthine layer morphogenesis] GO:0070062 [extracellular vesicular exosome] GO:0070436 [Grb2-EGFR complex] GO:0071479 [cellular response to ionizing radiation] GO:2000379 [positive regulation of reactive oxygen species metabolic process]	217	25.2	No
GRB2-003	ENSP00000376347 ENST00000392564	P62993 Show all » « Hide P62993 [Direct mapping] Growth factor receptor-bound protein 2 B0LPF3 [Target identity:100%; Query identity:100%] Growth factor receptor-bound protein 2 {ECO:0000313\|EMBL:ABY87532.1}; Growth factor receptor-bound protein 2, isoform CRA_a {ECO:0000313\|EMBL:EAW89270.1}; cDNA, FLJ96637, Homo sapiens growth factor receptor-bound protein 2 (GRB2), mRNA {ECO:0000313\|EMBL:BAG37940.1} J3KT38 [Target identity:50%; Query identity:100%] Growth factor receptor-bound protein 2 {ECO:0000313\|Ensembl:ENSP00000462785}	Show » « Hide Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005070 [SH3/SH2 adaptor activity] GO:0005154 [epidermal growth factor receptor binding] GO:0005168 [neurotrophin TRKA receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007265 [Ras protein signal transduction] GO:0007267 [cell-cell signaling] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008180 [COP9 signalosome] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016032 [viral process] GO:0017124 [SH3 domain binding] GO:0019901 [protein kinase binding] GO:0030168 [platelet activation] GO:0031295 [T cell costimulation] GO:0031623 [receptor internalization] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0043560 [insulin receptor substrate binding] GO:0044822 [poly(A) RNA binding] GO:0045087 [innate immune response] GO:0046875 [ephrin receptor binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050900 [leukocyte migration] GO:0070062 [extracellular vesicular exosome] GO:0070436 [Grb2-EGFR complex] GO:0071479 [cellular response to ionizing radiation] GO:2000379 [positive regulation of reactive oxygen species metabolic process]	217	25.2	No
GRB2-004	ENSP00000376346 ENST00000392563	P62993 Show all » « Hide P62993 [Direct mapping] Growth factor receptor-bound protein 2	Show » « Hide Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005070 [SH3/SH2 adaptor activity] GO:0005154 [epidermal growth factor receptor binding] GO:0005168 [neurotrophin TRKA receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007265 [Ras protein signal transduction] GO:0007267 [cell-cell signaling] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008180 [COP9 signalosome] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016032 [viral process] GO:0017124 [SH3 domain binding] GO:0019901 [protein kinase binding] GO:0030168 [platelet activation] GO:0031295 [T cell costimulation] GO:0031623 [receptor internalization] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0043560 [insulin receptor substrate binding] GO:0044822 [poly(A) RNA binding] GO:0045087 [innate immune response] GO:0046875 [ephrin receptor binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050900 [leukocyte migration] GO:0070062 [extracellular vesicular exosome] GO:0070436 [Grb2-EGFR complex] GO:0071479 [cellular response to ionizing radiation] GO:2000379 [positive regulation of reactive oxygen species metabolic process]	176	20.6	No
GRB2-007	ENSP00000462785 ENST00000582582	J3KT38 Show all » « Hide J3KT38 [Target identity:99%; Query identity:100%] Growth factor receptor-bound protein 2 {ECO:0000313\|Ensembl:ENSP00000462785}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	111	12.8	No
GRB2-008	ENSP00000464279 ENST00000578961	J3QRL5 Show all » « Hide J3QRL5 [Target identity:100%; Query identity:100%] Growth factor receptor-bound protein 2 {ECO:0000313\|Ensembl:ENSP00000464279}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	156	17.6	No
GRB2-009	ENSP00000463525 ENST00000581959		Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		42	4.7	No
GRB2-201	ENSP00000317360 ENST00000316615	P62993 Show all » « Hide P62993 [Direct mapping] Growth factor receptor-bound protein 2	Show » « Hide Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005070 [SH3/SH2 adaptor activity] GO:0005154 [epidermal growth factor receptor binding] GO:0005168 [neurotrophin TRKA receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007265 [Ras protein signal transduction] GO:0007267 [cell-cell signaling] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008180 [COP9 signalosome] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016032 [viral process] GO:0017124 [SH3 domain binding] GO:0019901 [protein kinase binding] GO:0030168 [platelet activation] GO:0031295 [T cell costimulation] GO:0031623 [receptor internalization] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0043560 [insulin receptor substrate binding] GO:0044822 [poly(A) RNA binding] GO:0045087 [innate immune response] GO:0046875 [ephrin receptor binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050900 [leukocyte migration] GO:0070062 [extracellular vesicular exosome] GO:0070436 [Grb2-EGFR complex] GO:0071479 [cellular response to ionizing radiation] GO:2000379 [positive regulation of reactive oxygen species metabolic process]	176	20.6	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx