CLK2

GENE INFORMATION

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Gene name

CLK2 (HGNC Symbol)

Synonyms

clk2

Description

CDC-like kinase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Chromosome

1

Cytoband

q22

Chromosome location (bp)

155262868 - 155278491

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000176444 (version 78.38)

Entrez gene

1196

UniProt

P49760 (UniProt - Evidence at protein level)

neXtProt

NX_P49760

Antibodypedia

CLK2 antibodies
 

PROTEIN VIEW

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CLK2-001
 
CLK2-002
 
CLK2-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLK2-001 ENSP00000357345
ENST00000368361
P49760
Show all »
Show » Show » 499 60.1 No 0
CLK2-002 ENSP00000354856
ENST00000361168
P49760
Show all »
Show » Show » 498 60 No 0
CLK2-003 ENSP00000347759
ENST00000355560
B1AVT0
Show all »
Show » Show » 497 59.9 No 0