ATP2A2 - Gene info - The Human Protein Atlas

Gene name

ATP2A2 (HGNC Symbol)

Synonyms

ATP2B, DAR, SERCA2

Description

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (HGNC Symbol)

Entrez gene summary

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]

Chromosome

Cytoband

q24.11

Chromosome location (bp)

110280756 - 110351093

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000174437 (version 78.38)

Entrez gene

488

UniProt

P16615 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP2A2-001

ENSP00000311186
ENST00000308664

P16615
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P16615 [Direct mapping]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

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Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0010460 [positive regulation of heart rate]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0019899 [enzyme binding]
GO:0031095 [platelet dense tubular network membrane]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034220 [ion transmembrane transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044548 [S100 protein binding]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0055119 [relaxation of cardiac muscle]
GO:0070296 [sarcoplasmic reticulum calcium ion transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:0086039 [calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential]

997

109.7

ATP2A2-003

ENSP00000440045
ENST00000539276

P16615
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P16615 [Direct mapping]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

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GO:0000166 [nucleotide binding]
GO:0002026 [regulation of the force of heart contraction]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006984 [ER-nucleus signaling pathway]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0010460 [positive regulation of heart rate]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0019899 [enzyme binding]
GO:0031095 [platelet dense tubular network membrane]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034220 [ion transmembrane transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044548 [S100 protein binding]
GO:0045822 [negative regulation of heart contraction]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0055119 [relaxation of cardiac muscle]
GO:0070296 [sarcoplasmic reticulum calcium ion transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:0086039 [calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential]

1042

114.8

ATP2A2-004

ENSP00000447406
ENST00000552636

F8W1Z7
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F8W1Z7 [Target identity:100%; Query identity:100%]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 {ECO:0000313|Ensembl:ENSP00000447406}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

5.3

ATP2A2-006

ENSP00000449454
ENST00000548169

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0006816 [calcium ion transport]
GO:0016021 [integral component of membrane]
GO:0046872 [metal ion binding]

933

102.5

ATP2A2-012

ENSP00000450407
ENST00000553144

P16615
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P16615 [Direct mapping]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

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Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005388 [calcium-transporting ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008152 [metabolic process]
GO:0008544 [epidermis development]
GO:0010460 [positive regulation of heart rate]
GO:0016020 [membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0019899 [enzyme binding]
GO:0031095 [platelet dense tubular network membrane]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034220 [ion transmembrane transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044548 [S100 protein binding]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0055119 [relaxation of cardiac muscle]
GO:0070296 [sarcoplasmic reticulum calcium ion transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:0086039 [calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential]

5.3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.