Tissue expression of DAG1 - Summary - The Human Protein Atlas

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DAG1

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	DAG1
Gene description	Dystroglycan 1 (dystrophin-associated glycoprotein 1)
Protein class	Cytoskeleton related proteins Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and membranous expression in a few tissues, including placental trophoblasts, skeletal and heart muscle.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Supportive based on 2 antibodies. CAB001960 , CAB016353
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	DAG1 (HGNC Symbol)
Synonyms	156DAG, A3a, AGRNR, DAG
Description	Dystroglycan 1 (dystrophin-associated glycoprotein 1) (HGNC Symbol)
Entrez gene summary	Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.[provided by RefSeq, Apr 2010]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49468703 - 49535618
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173402 (version 78.38)
Entrez gene	1605
UniProt	Q14118 (UniProt - Evidence at protein level)
neXtProt	NX_Q14118
Antibodypedia	DAG1 antibodies

PROTEIN BROWSER

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ENST00000308775		ENST00000418588		ENST00000419218		ENST00000421560		ENST00000428779		ENST00000430636		ENST00000431960		ENST00000435508		ENST00000452060		ENST00000452317		ENST00000515359		ENST00000538711		ENST00000539901		ENST00000541308		ENST00000545947

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
DAG1-001	ENSP00000312435 ENST00000308775	Q14118 Show all » « Hide Q14118 [Direct mapping] Dystroglycan Alpha-dystroglycan Beta-dystroglycan C9JQL4 [Target identity:13%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000388833} C9J196 [Target identity:11%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000412067} C9JYS1 [Target identity:10%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:5%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:4%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cytoskeleton related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001618 [virus receptor activity] GO:0003779 [actin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006509 [membrane protein ectodomain proteolysis] GO:0006607 [NLS-bearing protein import into nucleus] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0008307 [structural constituent of muscle] GO:0009615 [response to virus] GO:0015631 [tubulin binding] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017166 [vinculin binding] GO:0019048 [modulation by virus of host morphology or physiology] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0030198 [extracellular matrix organization] GO:0030336 [negative regulation of cell migration] GO:0034453 [microtubule anchoring] GO:0042169 [SH2 domain binding] GO:0043237 [laminin-1 binding] GO:0043409 [negative regulation of MAPK cascade] GO:0045211 [postsynaptic membrane] GO:0051393 [alpha-actinin binding] GO:0051898 [negative regulation of protein kinase B signaling] GO:0070062 [extracellular vesicular exosome] GO:0070938 [contractile ring]	895	97.4	Yes	1
DAG1-003	ENSP00000412067 ENST00000421560	C9J196 Show all » « Hide C9J196 [Target identity:100%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000412067} C9JYS1 [Target identity:89%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:83%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:81%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:49%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:38%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005509 [calcium ion binding] GO:0016020 [membrane]	106	11.2	Yes	0
DAG1-004	ENSP00000405859 ENST00000418588	C9J6Z6 Show all » « Hide C9J6Z6 [Target identity:100%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:97%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:59%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:46%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		88	9.5	Yes	0
DAG1-005	ENSP00000415321 ENST00000435508	C9JEH2 Show all » « Hide C9JEH2 [Target identity:100%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:78%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		52	5.8	Yes	0
DAG1-006	ENSP00000387859 ENST00000452317	C9JY76 Show all » « Hide C9JY76 [Target identity:100%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		41	4.5	Yes	0
DAG1-007	ENSP00000410145 ENST00000452060	C9JEN1 Show all » « Hide C9JEN1 [Target identity:100%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:60%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:47%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		86	9.4	Yes	0
DAG1-009	ENSP00000401382 ENST00000428779	C9JYS1 Show all » « Hide C9JYS1 [Target identity:98%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:91%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:89%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:54%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:42%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		96	10.3	Yes	0
DAG1-011	ENSP00000402443 ENST00000419218		Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		15	1.6	No	0
DAG1-012	ENSP00000401805 ENST00000430636		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		9	1	No	0
DAG1-015	ENSP00000388833 ENST00000431960	C9JQL4 Show all » « Hide C9JQL4 [Target identity:100%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000388833} C9J196 [Target identity:90%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000412067} C9JYS1 [Target identity:81%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:75%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:73%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:44%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:35%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005509 [calcium ion binding] GO:0016020 [membrane]	117	12.6	Yes	0
DAG1-201	ENSP00000440705 ENST00000515359	Q14118 Show all » « Hide Q14118 [Direct mapping] Dystroglycan Alpha-dystroglycan Beta-dystroglycan C9JQL4 [Target identity:13%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000388833} C9J196 [Target identity:11%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000412067} C9JYS1 [Target identity:10%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:5%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:4%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cytoskeleton related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001618 [virus receptor activity] GO:0003779 [actin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006509 [membrane protein ectodomain proteolysis] GO:0006607 [NLS-bearing protein import into nucleus] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0008307 [structural constituent of muscle] GO:0009615 [response to virus] GO:0015631 [tubulin binding] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017166 [vinculin binding] GO:0019048 [modulation by virus of host morphology or physiology] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0030198 [extracellular matrix organization] GO:0030336 [negative regulation of cell migration] GO:0034453 [microtubule anchoring] GO:0042169 [SH2 domain binding] GO:0043237 [laminin-1 binding] GO:0043409 [negative regulation of MAPK cascade] GO:0045211 [postsynaptic membrane] GO:0051393 [alpha-actinin binding] GO:0051898 [negative regulation of protein kinase B signaling] GO:0070062 [extracellular vesicular exosome] GO:0070938 [contractile ring]	895	97.4	Yes	1
DAG1-202	ENSP00000438421 ENST00000538711	Q14118 Show all » « Hide Q14118 [Direct mapping] Dystroglycan Alpha-dystroglycan Beta-dystroglycan C9JQL4 [Target identity:13%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000388833} C9J196 [Target identity:11%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000412067} C9JYS1 [Target identity:10%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:5%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:4%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cytoskeleton related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001618 [virus receptor activity] GO:0003779 [actin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006509 [membrane protein ectodomain proteolysis] GO:0006607 [NLS-bearing protein import into nucleus] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0008307 [structural constituent of muscle] GO:0009615 [response to virus] GO:0015631 [tubulin binding] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017166 [vinculin binding] GO:0019048 [modulation by virus of host morphology or physiology] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0030198 [extracellular matrix organization] GO:0030336 [negative regulation of cell migration] GO:0034453 [microtubule anchoring] GO:0042169 [SH2 domain binding] GO:0043237 [laminin-1 binding] GO:0043409 [negative regulation of MAPK cascade] GO:0045211 [postsynaptic membrane] GO:0051393 [alpha-actinin binding] GO:0051898 [negative regulation of protein kinase B signaling] GO:0070062 [extracellular vesicular exosome] GO:0070938 [contractile ring]	895	97.4	Yes	1
DAG1-203	ENSP00000439334 ENST00000539901	Q14118 Show all » « Hide Q14118 [Direct mapping] Dystroglycan Alpha-dystroglycan Beta-dystroglycan C9JQL4 [Target identity:13%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000388833} C9J196 [Target identity:11%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000412067} C9JYS1 [Target identity:10%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:5%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:4%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cytoskeleton related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001618 [virus receptor activity] GO:0003779 [actin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006509 [membrane protein ectodomain proteolysis] GO:0006607 [NLS-bearing protein import into nucleus] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0008307 [structural constituent of muscle] GO:0009615 [response to virus] GO:0015631 [tubulin binding] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017166 [vinculin binding] GO:0019048 [modulation by virus of host morphology or physiology] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0030198 [extracellular matrix organization] GO:0030336 [negative regulation of cell migration] GO:0034453 [microtubule anchoring] GO:0042169 [SH2 domain binding] GO:0043237 [laminin-1 binding] GO:0043409 [negative regulation of MAPK cascade] GO:0045211 [postsynaptic membrane] GO:0051393 [alpha-actinin binding] GO:0051898 [negative regulation of protein kinase B signaling] GO:0070062 [extracellular vesicular exosome] GO:0070938 [contractile ring]	895	97.4	Yes	1
DAG1-204	ENSP00000440590 ENST00000541308	Q14118 Show all » « Hide Q14118 [Direct mapping] Dystroglycan Alpha-dystroglycan Beta-dystroglycan C9JQL4 [Target identity:13%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000388833} C9J196 [Target identity:11%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000412067} C9JYS1 [Target identity:10%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:5%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:4%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cytoskeleton related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001618 [virus receptor activity] GO:0003779 [actin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006509 [membrane protein ectodomain proteolysis] GO:0006607 [NLS-bearing protein import into nucleus] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0008307 [structural constituent of muscle] GO:0009615 [response to virus] GO:0015631 [tubulin binding] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017166 [vinculin binding] GO:0019048 [modulation by virus of host morphology or physiology] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0030198 [extracellular matrix organization] GO:0030336 [negative regulation of cell migration] GO:0034453 [microtubule anchoring] GO:0042169 [SH2 domain binding] GO:0043237 [laminin-1 binding] GO:0043409 [negative regulation of MAPK cascade] GO:0045211 [postsynaptic membrane] GO:0051393 [alpha-actinin binding] GO:0051898 [negative regulation of protein kinase B signaling] GO:0070062 [extracellular vesicular exosome] GO:0070938 [contractile ring]	895	97.4	Yes	1
DAG1-205	ENSP00000442600 ENST00000545947	Q14118 Show all » « Hide Q14118 [Direct mapping] Dystroglycan Alpha-dystroglycan Beta-dystroglycan C9JQL4 [Target identity:13%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000388833} C9J196 [Target identity:11%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000412067} C9JYS1 [Target identity:10%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:5%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:4%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cytoskeleton related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001618 [virus receptor activity] GO:0002011 [morphogenesis of an epithelial sheet] GO:0002162 [dystroglycan binding] GO:0003779 [actin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005913 [cell-cell adherens junction] GO:0005925 [focal adhesion] GO:0006509 [membrane protein ectodomain proteolysis] GO:0006607 [NLS-bearing protein import into nucleus] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0008307 [structural constituent of muscle] GO:0009279 [cell outer membrane] GO:0009615 [response to virus] GO:0014044 [Schwann cell development] GO:0015631 [tubulin binding] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016011 [dystroglycan complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016340 [calcium-dependent cell-matrix adhesion] GO:0017166 [vinculin binding] GO:0019048 [modulation by virus of host morphology or physiology] GO:0021682 [nerve maturation] GO:0022011 [myelination in peripheral nervous system] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0030198 [extracellular matrix organization] GO:0030336 [negative regulation of cell migration] GO:0032403 [protein complex binding] GO:0033268 [node of Ranvier] GO:0034453 [microtubule anchoring] GO:0042169 [SH2 domain binding] GO:0042383 [sarcolemma] GO:0043034 [costamere] GO:0043237 [laminin-1 binding] GO:0043409 [negative regulation of MAPK cascade] GO:0043434 [response to peptide hormone] GO:0045121 [membrane raft] GO:0045211 [postsynaptic membrane] GO:0051393 [alpha-actinin binding] GO:0051898 [negative regulation of protein kinase B signaling] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0070062 [extracellular vesicular exosome] GO:0070938 [contractile ring] GO:0071679 [commissural neuron axon guidance] GO:0071711 [basement membrane organization]	895	97.4	Yes	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx