DAG1 - Gene info - The Human Protein Atlas

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DAG1

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TISSUE

SUBCELL

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CELL LINE

CANCER

GENE INFORMATION

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Gene name	DAG1 (HGNC Symbol)
Synonyms	156DAG, A3a, AGRNR, DAG
Description	Dystroglycan 1 (dystrophin-associated glycoprotein 1) (HGNC Symbol)
Entrez gene summary	Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.[provided by RefSeq, Apr 2010]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49468703 - 49535618
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173402 (version 78.38)
Entrez gene	1605
UniProt	Q14118 (UniProt - Evidence at protein level)
neXtProt	NX_Q14118
Antibodypedia	DAG1 antibodies

PROTEIN VIEW

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DAG1-001		DAG1-003		DAG1-004		DAG1-005		DAG1-006		DAG1-007		DAG1-009		DAG1-011		DAG1-012		DAG1-015		DAG1-201		DAG1-202		DAG1-203		DAG1-204		DAG1-205

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
DAG1-001	ENSP00000312435 ENST00000308775	Q14118 Show all » « Hide Q14118 [Direct mapping] Dystroglycan Alpha-dystroglycan Beta-dystroglycan C9JQL4 [Target identity:13%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000388833} C9J196 [Target identity:11%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000412067} C9JYS1 [Target identity:10%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:5%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:4%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cytoskeleton related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001618 [virus receptor activity] GO:0003779 [actin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006509 [membrane protein ectodomain proteolysis] GO:0006607 [NLS-bearing protein import into nucleus] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0008307 [structural constituent of muscle] GO:0009615 [response to virus] GO:0015631 [tubulin binding] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017166 [vinculin binding] GO:0019048 [modulation by virus of host morphology or physiology] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0030198 [extracellular matrix organization] GO:0030336 [negative regulation of cell migration] GO:0034453 [microtubule anchoring] GO:0042169 [SH2 domain binding] GO:0043237 [laminin-1 binding] GO:0043409 [negative regulation of MAPK cascade] GO:0045211 [postsynaptic membrane] GO:0051393 [alpha-actinin binding] GO:0051898 [negative regulation of protein kinase B signaling] GO:0070062 [extracellular vesicular exosome] GO:0070938 [contractile ring]	895	97.4	Yes	1
DAG1-003	ENSP00000412067 ENST00000421560	C9J196 Show all » « Hide C9J196 [Target identity:100%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000412067} C9JYS1 [Target identity:89%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:83%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:81%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:49%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:38%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005509 [calcium ion binding] GO:0016020 [membrane]	106	11.2	Yes	0
DAG1-004	ENSP00000405859 ENST00000418588	C9J6Z6 Show all » « Hide C9J6Z6 [Target identity:100%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:97%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:59%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:46%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		88	9.5	Yes	0
DAG1-005	ENSP00000415321 ENST00000435508	C9JEH2 Show all » « Hide C9JEH2 [Target identity:100%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:78%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		52	5.8	Yes	0
DAG1-006	ENSP00000387859 ENST00000452317	C9JY76 Show all » « Hide C9JY76 [Target identity:100%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		41	4.5	Yes	0
DAG1-007	ENSP00000410145 ENST00000452060	C9JEN1 Show all » « Hide C9JEN1 [Target identity:100%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:60%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:47%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		86	9.4	Yes	0
DAG1-009	ENSP00000401382 ENST00000428779	C9JYS1 Show all » « Hide C9JYS1 [Target identity:98%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:91%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:89%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:54%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:42%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		96	10.3	Yes	0
DAG1-011	ENSP00000402443 ENST00000419218		Show » « Hide SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		15	1.6	No	0
DAG1-012	ENSP00000401805 ENST00000430636		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		9	1	No	0
DAG1-015	ENSP00000388833 ENST00000431960	C9JQL4 Show all » « Hide C9JQL4 [Target identity:100%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000388833} C9J196 [Target identity:90%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000412067} C9JYS1 [Target identity:81%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:75%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:73%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:44%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:35%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005509 [calcium ion binding] GO:0016020 [membrane]	117	12.6	Yes	0
DAG1-201	ENSP00000440705 ENST00000515359	Q14118 Show all » « Hide Q14118 [Direct mapping] Dystroglycan Alpha-dystroglycan Beta-dystroglycan C9JQL4 [Target identity:13%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000388833} C9J196 [Target identity:11%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000412067} C9JYS1 [Target identity:10%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:5%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:4%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cytoskeleton related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001618 [virus receptor activity] GO:0003779 [actin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006509 [membrane protein ectodomain proteolysis] GO:0006607 [NLS-bearing protein import into nucleus] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0008307 [structural constituent of muscle] GO:0009615 [response to virus] GO:0015631 [tubulin binding] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017166 [vinculin binding] GO:0019048 [modulation by virus of host morphology or physiology] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0030198 [extracellular matrix organization] GO:0030336 [negative regulation of cell migration] GO:0034453 [microtubule anchoring] GO:0042169 [SH2 domain binding] GO:0043237 [laminin-1 binding] GO:0043409 [negative regulation of MAPK cascade] GO:0045211 [postsynaptic membrane] GO:0051393 [alpha-actinin binding] GO:0051898 [negative regulation of protein kinase B signaling] GO:0070062 [extracellular vesicular exosome] GO:0070938 [contractile ring]	895	97.4	Yes	1
DAG1-202	ENSP00000438421 ENST00000538711	Q14118 Show all » « Hide Q14118 [Direct mapping] Dystroglycan Alpha-dystroglycan Beta-dystroglycan C9JQL4 [Target identity:13%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000388833} C9J196 [Target identity:11%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000412067} C9JYS1 [Target identity:10%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:5%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:4%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cytoskeleton related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001618 [virus receptor activity] GO:0003779 [actin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006509 [membrane protein ectodomain proteolysis] GO:0006607 [NLS-bearing protein import into nucleus] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0008307 [structural constituent of muscle] GO:0009615 [response to virus] GO:0015631 [tubulin binding] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017166 [vinculin binding] GO:0019048 [modulation by virus of host morphology or physiology] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0030198 [extracellular matrix organization] GO:0030336 [negative regulation of cell migration] GO:0034453 [microtubule anchoring] GO:0042169 [SH2 domain binding] GO:0043237 [laminin-1 binding] GO:0043409 [negative regulation of MAPK cascade] GO:0045211 [postsynaptic membrane] GO:0051393 [alpha-actinin binding] GO:0051898 [negative regulation of protein kinase B signaling] GO:0070062 [extracellular vesicular exosome] GO:0070938 [contractile ring]	895	97.4	Yes	1
DAG1-203	ENSP00000439334 ENST00000539901	Q14118 Show all » « Hide Q14118 [Direct mapping] Dystroglycan Alpha-dystroglycan Beta-dystroglycan C9JQL4 [Target identity:13%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000388833} C9J196 [Target identity:11%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000412067} C9JYS1 [Target identity:10%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:5%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:4%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cytoskeleton related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001618 [virus receptor activity] GO:0003779 [actin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006509 [membrane protein ectodomain proteolysis] GO:0006607 [NLS-bearing protein import into nucleus] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0008307 [structural constituent of muscle] GO:0009615 [response to virus] GO:0015631 [tubulin binding] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017166 [vinculin binding] GO:0019048 [modulation by virus of host morphology or physiology] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0030198 [extracellular matrix organization] GO:0030336 [negative regulation of cell migration] GO:0034453 [microtubule anchoring] GO:0042169 [SH2 domain binding] GO:0043237 [laminin-1 binding] GO:0043409 [negative regulation of MAPK cascade] GO:0045211 [postsynaptic membrane] GO:0051393 [alpha-actinin binding] GO:0051898 [negative regulation of protein kinase B signaling] GO:0070062 [extracellular vesicular exosome] GO:0070938 [contractile ring]	895	97.4	Yes	1
DAG1-204	ENSP00000440590 ENST00000541308	Q14118 Show all » « Hide Q14118 [Direct mapping] Dystroglycan Alpha-dystroglycan Beta-dystroglycan C9JQL4 [Target identity:13%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000388833} C9J196 [Target identity:11%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000412067} C9JYS1 [Target identity:10%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:5%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:4%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cytoskeleton related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001618 [virus receptor activity] GO:0003779 [actin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006509 [membrane protein ectodomain proteolysis] GO:0006607 [NLS-bearing protein import into nucleus] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0008307 [structural constituent of muscle] GO:0009615 [response to virus] GO:0015631 [tubulin binding] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017166 [vinculin binding] GO:0019048 [modulation by virus of host morphology or physiology] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0030198 [extracellular matrix organization] GO:0030336 [negative regulation of cell migration] GO:0034453 [microtubule anchoring] GO:0042169 [SH2 domain binding] GO:0043237 [laminin-1 binding] GO:0043409 [negative regulation of MAPK cascade] GO:0045211 [postsynaptic membrane] GO:0051393 [alpha-actinin binding] GO:0051898 [negative regulation of protein kinase B signaling] GO:0070062 [extracellular vesicular exosome] GO:0070938 [contractile ring]	895	97.4	Yes	1
DAG1-205	ENSP00000442600 ENST00000545947	Q14118 Show all » « Hide Q14118 [Direct mapping] Dystroglycan Alpha-dystroglycan Beta-dystroglycan C9JQL4 [Target identity:13%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000388833} C9J196 [Target identity:11%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000412067} C9JYS1 [Target identity:10%; Query identity:100%] Dystroglycan {ECO:0000313\|Ensembl:ENSP00000401382} C9J6Z6 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000405859} C9JEN1 [Target identity:9%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000410145} C9JEH2 [Target identity:5%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000415321} C9JY76 [Target identity:4%; Query identity:100%] Alpha-dystroglycan {ECO:0000313\|Ensembl:ENSP00000387859}	Show » « Hide Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cytoskeleton related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001618 [virus receptor activity] GO:0002011 [morphogenesis of an epithelial sheet] GO:0002162 [dystroglycan binding] GO:0003779 [actin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005913 [cell-cell adherens junction] GO:0005925 [focal adhesion] GO:0006509 [membrane protein ectodomain proteolysis] GO:0006607 [NLS-bearing protein import into nucleus] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0008307 [structural constituent of muscle] GO:0009279 [cell outer membrane] GO:0009615 [response to virus] GO:0014044 [Schwann cell development] GO:0015631 [tubulin binding] GO:0016010 [dystrophin-associated glycoprotein complex] GO:0016011 [dystroglycan complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016340 [calcium-dependent cell-matrix adhesion] GO:0017166 [vinculin binding] GO:0019048 [modulation by virus of host morphology or physiology] GO:0021682 [nerve maturation] GO:0022011 [myelination in peripheral nervous system] GO:0030027 [lamellipodium] GO:0030175 [filopodium] GO:0030198 [extracellular matrix organization] GO:0030336 [negative regulation of cell migration] GO:0032403 [protein complex binding] GO:0033268 [node of Ranvier] GO:0034453 [microtubule anchoring] GO:0042169 [SH2 domain binding] GO:0042383 [sarcolemma] GO:0043034 [costamere] GO:0043237 [laminin-1 binding] GO:0043409 [negative regulation of MAPK cascade] GO:0043434 [response to peptide hormone] GO:0045121 [membrane raft] GO:0045211 [postsynaptic membrane] GO:0051393 [alpha-actinin binding] GO:0051898 [negative regulation of protein kinase B signaling] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0070062 [extracellular vesicular exosome] GO:0070938 [contractile ring] GO:0071679 [commissural neuron axon guidance] GO:0071711 [basement membrane organization]	895	97.4	Yes	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.