ADCY5 - Gene info - The Human Protein Atlas

Gene name

ADCY5 (HGNC Symbol)

Synonyms

AC5

Description

Adenylate cyclase 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Chromosome

Cytoband

q21.1

Chromosome location (bp)

123282296 - 123449758

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173175 (version 78.38)

Entrez gene

111

UniProt

O95622 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADCY5-001

ENSP00000419361
ENST00000462833

O95622
Show all » « Hide

O95622 [Direct mapping]
Adenylate cyclase type 5
B7Z2C7 [Target identity:77%; Query identity:100%]
cDNA FLJ55968, highly similar to Adenylate cyclase type 5 {ECO:0000313|EMBL:BAH11813.1}
C9JRT8 [Target identity:39%; Query identity:100%]
Uncharacterized protein {ECO:0000313|Ensembl:ENSP00000420082}
B7Z801 [Target identity:34%; Query identity:100%]
cDNA FLJ52910, highly similar to Adenylate cyclase type 5 {ECO:0000313|EMBL:BAH13787.1}
C9JQ38 [Target identity:7%; Query identity:100%]
Adenylate cyclase type 5 {ECO:0000313|Ensembl:ENSP00000420252}

Show » « Hide

Enzymes
   ENZYME proteins
   Lyases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)

Show » « Hide

GO:0000166 [nucleotide binding]
GO:0001973 [adenosine receptor signaling pathway]
GO:0004016 [adenylate cyclase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006171 [cAMP biosynthetic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0007626 [locomotory behavior]
GO:0008179 [adenylate cyclase binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050885 [neuromuscular process controlling balance]
GO:0055085 [transmembrane transport]
GO:0071377 [cellular response to glucagon stimulus]
GO:0072372 [primary cilium]

1261

138.9

ADCY5-002

ENSP00000418537
ENST00000491190

B3KWA8
Show all » « Hide

B3KWA8 [Target identity:100%; Query identity:100%]
Adenylate cyclase type 5 {ECO:0000313|Ensembl:ENSP00000418537}; cDNA FLJ42701 fis, clone BRAMY3004919, highly similar to Adenylate cyclase type 5 {ECO:0000313|EMBL:BAG54070.1}
C9JRT8 [Target identity:53%; Query identity:100%]
Uncharacterized protein {ECO:0000313|Ensembl:ENSP00000420082}
C9JQ38 [Target identity:9%; Query identity:100%]
Adenylate cyclase type 5 {ECO:0000313|Ensembl:ENSP00000420252}

Show » « Hide

Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)

Show » « Hide

GO:0000166 [nucleotide binding]
GO:0004016 [adenylate cyclase activity]
GO:0006171 [cAMP biosynthetic process]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]

919

103.9

ADCY5-003

ENSP00000308685
ENST00000309879

O95622
Show all » « Hide

O95622 [Direct mapping]
Adenylate cyclase type 5
C9JRT8 [Target identity:54%; Query identity:100%]
Uncharacterized protein {ECO:0000313|Ensembl:ENSP00000420082}
B7Z801 [Target identity:47%; Query identity:100%]
cDNA FLJ52910, highly similar to Adenylate cyclase type 5 {ECO:0000313|EMBL:BAH13787.1}
C9JQ38 [Target identity:9%; Query identity:100%]
Adenylate cyclase type 5 {ECO:0000313|Ensembl:ENSP00000420252}

Show » « Hide

Enzymes
   ENZYME proteins
   Lyases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)

Show » « Hide

GO:0000166 [nucleotide binding]
GO:0004016 [adenylate cyclase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006171 [cAMP biosynthetic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007268 [synaptic transmission]
GO:0008179 [adenylate cyclase binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0055085 [transmembrane transport]
GO:0071377 [cellular response to glucagon stimulus]
GO:0072372 [primary cilium]

911

102.6

ADCY5-004

ENSP00000420082
ENST00000466617

C9JRT8
Show all » « Hide

C9JRT8 [Target identity:100%; Query identity:100%]
Uncharacterized protein {ECO:0000313|Ensembl:ENSP00000420082}
C9JQ38 [Target identity:18%; Query identity:100%]
Adenylate cyclase type 5 {ECO:0000313|Ensembl:ENSP00000420252}

Show » « Hide

Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)

Show » « Hide

492

55.5

ADCY5-005

ENSP00000420252
ENST00000483566

C9JQ38
Show all » « Hide

C9JQ38 [Target identity:100%; Query identity:100%]
Adenylate cyclase type 5 {ECO:0000313|Ensembl:ENSP00000420252}

Show » « Hide

Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Show » « Hide

GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]

10.3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.