Tissue expression of ESRRA - Summary - The Human Protein Atlas

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ESRRA

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	ESRRA
Gene description	Estrogen-related receptor alpha
Protein class	Nuclear receptors Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability	Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW ? »
Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation. For genes with available protein data for which a knowledge-based annotation could not be performed, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	ESRRA (HGNC Symbol)
Synonyms	ERR1, ERRa, ERRalpha, ESRL1, NR3B1
Description	Estrogen-related receptor alpha (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	64305572 - 64316743
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173153 (version 78.38)
Entrez gene	2101
UniProt	P11474 (UniProt - Evidence at protein level)
neXtProt	NX_P11474
Antibodypedia	ESRRA antibodies

PROTEIN BROWSER

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ENST00000000442		ENST00000405666		ENST00000406310		ENST00000468670		ENST00000539594		ENST00000545035

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
ESRRA-001	ENSP00000385971 ENST00000406310	P11474 Show all » « Hide P11474 [Direct mapping] Steroid hormone receptor ERR1 F5GWT5 [Target identity:25%; Query identity:100%] Steroid hormone receptor ERR1 {ECO:0000313\|Ensembl:ENSP00000441970} Q96F89 [Target identity:13%; Query identity:100%] Putative uncharacterized protein {ECO:0000313\|EMBL:AAH11528.1}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0015630 [microtubule cytoskeleton] GO:0019904 [protein domain specific binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045171 [intercellular bridge] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	422	45.4	No
ESRRA-002	ENSP00000000442 ENST00000000442	P11474 Show all » « Hide P11474 [Direct mapping] Steroid hormone receptor ERR1 Q569H8 [Target identity:100%; Query identity:100%] ESRRA protein {ECO:0000313\|EMBL:AAH92470.1}; Estrogen-related nuclear receptor alpha {ECO:0000313\|EMBL:ADZ17378.1}; Estrogen-related receptor alpha {ECO:0000313\|EMBL:AAH63795.2}; HCG2016877, isoform CRA_b {ECO:0000313\|EMBL:EAW74246.1} Q96I02 [Target identity:75%; Query identity:100%] ESRRA protein {ECO:0000313\|EMBL:AAH07915.2} F5H0E9 [Target identity:38%; Query identity:100%] Steroid hormone receptor ERR1 {ECO:0000313\|Ensembl:ENSP00000439896} F5GWT5 [Target identity:25%; Query identity:100%] Steroid hormone receptor ERR1 {ECO:0000313\|Ensembl:ENSP00000441970} Q96F89 [Target identity:13%; Query identity:100%] Putative uncharacterized protein {ECO:0000313\|EMBL:AAH11528.1}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0015630 [microtubule cytoskeleton] GO:0019904 [protein domain specific binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045171 [intercellular bridge] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	423	45.5	No
ESRRA-003	ENSP00000384851 ENST00000405666	P11474 Show all » « Hide P11474 [Direct mapping] Steroid hormone receptor ERR1 Q569H8 [Target identity:100%; Query identity:100%] ESRRA protein {ECO:0000313\|EMBL:AAH92470.1}; Estrogen-related nuclear receptor alpha {ECO:0000313\|EMBL:ADZ17378.1}; Estrogen-related receptor alpha {ECO:0000313\|EMBL:AAH63795.2}; HCG2016877, isoform CRA_b {ECO:0000313\|EMBL:EAW74246.1} Q96I02 [Target identity:75%; Query identity:100%] ESRRA protein {ECO:0000313\|EMBL:AAH07915.2} F5H0E9 [Target identity:38%; Query identity:100%] Steroid hormone receptor ERR1 {ECO:0000313\|Ensembl:ENSP00000439896} F5GWT5 [Target identity:25%; Query identity:100%] Steroid hormone receptor ERR1 {ECO:0000313\|Ensembl:ENSP00000441970} Q96F89 [Target identity:13%; Query identity:100%] Putative uncharacterized protein {ECO:0000313\|EMBL:AAH11528.1}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001078 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0015630 [microtubule cytoskeleton] GO:0019904 [protein domain specific binding] GO:0030278 [regulation of ossification] GO:0030522 [intracellular receptor signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045171 [intercellular bridge] GO:0045667 [regulation of osteoblast differentiation] GO:0045670 [regulation of osteoclast differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051216 [cartilage development]	423	45.5	No
ESRRA-004	ENSP00000441970 ENST00000468670	F5GWT5 Show all » « Hide F5GWT5 [Target identity:100%; Query identity:100%] Steroid hormone receptor ERR1 {ECO:0000313\|Ensembl:ENSP00000441970}	Show » « Hide Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0015630 [microtubule cytoskeleton] GO:0043565 [sequence-specific DNA binding] GO:0045171 [intercellular bridge]	109	11.2	No
ESRRA-006	ENSP00000444710 ENST00000545035		Show » « Hide Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043401 [steroid hormone mediated signaling pathway]	198	21.3	No
ESRRA-007	ENSP00000439896 ENST00000539594	F5H0E9 Show all » « Hide F5H0E9 [Target identity:100%; Query identity:100%] Steroid hormone receptor ERR1 {ECO:0000313\|Ensembl:ENSP00000439896}	Show » « Hide Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043401 [steroid hormone mediated signaling pathway]	162	17.4	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx