CHRNB1

CANCER ATLAS

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Gene description

Cholinergic receptor, nicotinic, beta 1 (muscle)

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins, Transporters

Protein evidence

Evidence at protein level
 
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

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HPA005822
 
 
CAB011200
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 
 

Staining summary

Most malignant tissues displayed weak to moderate cytoplasmic staining, however single cases of colo-rectal cancer and embryonal carcinoma of testis were strongly positive. Negative cases were seen in all cancers. Poorly differentiated squamous cell carcinomas showed less immunoreactivity as compared to well differentiated.
 

Level of antibody staining/expression





High
Medium
Low
Not detected