B2M - Gene info - The Human Protein Atlas

Gene name

B2M

Synonyms

Description

Beta-2-microglobulin (HGNC Symbol)

Entrez gene summary

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

Chromosome

Cytoband

q21.1

Chromosome location (bp)

44711477 - 44718877

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166710 (version 78.38)

Entrez gene

567

UniProt

P61769 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

B2M-001

ENSP00000452780
ENST00000558401

P61769
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P61769 [Direct mapping]
Beta-2-microglobulin Beta-2-microglobulin form pI 5.3
H0YLF3 [Target identity:59%; Query identity:100%]
Beta-2-microglobulin form pI 5.3 {ECO:0000313|Ensembl:ENSP00000453186}
Q9UM88 [Target identity:24%; Query identity:100%]
Beta 2-microglobulin protein {ECO:0000313|EMBL:AAD14388.1}

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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000139 [Golgi membrane]
GO:0001895 [retina homeostasis]
GO:0001916 [positive regulation of T cell mediated cytotoxicity]
GO:0002237 [response to molecule of bacterial origin]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent]
GO:0002481 [antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0009897 [external side of plasma membrane]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030670 [phagocytic vesicle membrane]
GO:0031901 [early endosome membrane]
GO:0031905 [early endosome lumen]
GO:0033077 [T cell differentiation in thymus]
GO:0042026 [protein refolding]
GO:0042493 [response to drug]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042612 [MHC class I protein complex]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0046686 [response to cadmium ion]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050776 [regulation of immune response]
GO:0055072 [iron ion homeostasis]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0070062 [extracellular vesicular exosome]

119

13.7

Yes

B2M-006

ENSP00000453350
ENST00000559916

P61769
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GO:0000139 [Golgi membrane]
GO:0001895 [retina homeostasis]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030670 [phagocytic vesicle membrane]
GO:0031901 [early endosome membrane]
GO:0031905 [early endosome lumen]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042612 [MHC class I protein complex]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050776 [regulation of immune response]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0070062 [extracellular vesicular exosome]

119

13.7

Yes

B2M-201

ENSP00000437604
ENST00000544417

Q9UM88
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Q9UM88 [Target identity:28%; Query identity:100%]
Beta 2-microglobulin protein {ECO:0000313|EMBL:AAD14388.1}

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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

101

11.7

Yes

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.