Tissue expression of PRKCB - Summary - The Human Protein Atlas

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PRKCB

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	PRKCB
Gene description	Protein kinase C, beta
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic or nuclear expression in several tissues, for example leukocytes, kidney, stomach and CNS.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Uncertain based on 2 antibodies. HPA048321 , CAB003843
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Tissue enhanced (cerebral cortex)

Organ

Expression

GTEx dataset

RNA tissue category:

Tissue enhanced (cerebral cortex)

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	PRKCB (HGNC Symbol)
Synonyms	PKCB, PRKCB1, PRKCB2
Description	Protein kinase C, beta (HGNC Symbol)
Entrez gene summary	Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband
Chromosome location (bp)	23836001 - 24220611
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166501 (version 78.38)
Entrez gene	5579
UniProt	P05771 (UniProt - Evidence at protein level)
neXtProt	NX_P05771
Antibodypedia	PRKCB antibodies

PROTEIN BROWSER

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ENST00000303531		ENST00000321728		ENST00000466124		ENST00000472066		ENST00000498058		ENST00000498739

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
PRKCB-001	ENSP00000318315 ENST00000321728	P05771 Show all » « Hide P05771 [Direct mapping] Protein kinase C beta type I3L1Z0 [Target identity:17%; Query identity:100%] Protein kinase C beta type {ECO:0000313\|Ensembl:ENSP00000459227}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003682 [chromatin binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004697 [protein kinase C activity] GO:0004713 [protein tyrosine kinase activity] GO:0005080 [protein kinase C binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008270 [zinc ion binding] GO:0010829 [negative regulation of glucose transport] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0030168 [platelet activation] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0035403 [histone kinase activity (H3-T6 specific)] GO:0035408 [histone H3-T6 phosphorylation] GO:0035556 [intracellular signal transduction] GO:0042113 [B cell activation] GO:0042393 [histone binding] GO:0042953 [lipoprotein transport] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045766 [positive regulation of angiogenesis] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0050681 [androgen receptor binding] GO:0050853 [B cell receptor signaling pathway] GO:0050861 [positive regulation of B cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0070062 [extracellular vesicular exosome]	671	76.9	No
PRKCB-002	ENSP00000305355 ENST00000303531	P05771 Show all » « Hide P05771 [Direct mapping] Protein kinase C beta type I3L1Z0 [Target identity:17%; Query identity:100%] Protein kinase C beta type {ECO:0000313\|Ensembl:ENSP00000459227}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003682 [chromatin binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004697 [protein kinase C activity] GO:0004713 [protein tyrosine kinase activity] GO:0005080 [protein kinase C binding] GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008270 [zinc ion binding] GO:0010829 [negative regulation of glucose transport] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0030168 [platelet activation] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0035403 [histone kinase activity (H3-T6 specific)] GO:0035408 [histone H3-T6 phosphorylation] GO:0035556 [intracellular signal transduction] GO:0042113 [B cell activation] GO:0042393 [histone binding] GO:0042953 [lipoprotein transport] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045766 [positive regulation of angiogenesis] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0050681 [androgen receptor binding] GO:0050853 [B cell receptor signaling pathway] GO:0050861 [positive regulation of B cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0070062 [extracellular vesicular exosome] GO:0071322 [cellular response to carbohydrate stimulus]	673	77	No
PRKCB-003	ENSP00000454428 ENST00000498058	P05771 Show all » « Hide P05771 [Direct mapping] Protein kinase C beta type	Show » « Hide Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003682 [chromatin binding] GO:0004674 [protein serine/threonine kinase activity] GO:0004697 [protein kinase C activity] GO:0005080 [protein kinase C binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008270 [zinc ion binding] GO:0010829 [negative regulation of glucose transport] GO:0030168 [platelet activation] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0035403 [histone kinase activity (H3-T6 specific)] GO:0035408 [histone H3-T6 phosphorylation] GO:0035556 [intracellular signal transduction] GO:0042113 [B cell activation] GO:0042393 [histone binding] GO:0042953 [lipoprotein transport] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045766 [positive regulation of angiogenesis] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0050681 [androgen receptor binding] GO:0050853 [B cell receptor signaling pathway] GO:0050861 [positive regulation of B cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0070062 [extracellular vesicular exosome]	57	6.4	No
PRKCB-004	ENSP00000459227 ENST00000498739	I3L1Z0 Show all » « Hide I3L1Z0 [Target identity:100%; Query identity:100%] Protein kinase C beta type {ECO:0000313\|Ensembl:ENSP00000459227}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	119	13.8	No
PRKCB-007	ENSP00000457980 ENST00000472066	H3BV73 Show all » « Hide H3BV73 [Target identity:100%; Query identity:100%] Protein kinase C beta type {ECO:0000313\|Ensembl:ENSP00000457980}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	130	14.9	No
PRKCB-010	ENSP00000458564 ENST00000466124		Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0016772 [transferase activity, transferring phosphorus-containing groups]	122	14	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx