POLR2H - Gene info - The Human Protein Atlas

Gene name

POLR2H (HGNC Symbol)

Synonyms

RPB8

Description

Polymerase (RNA) II (DNA directed) polypeptide H (HGNC Symbol)

Entrez gene summary

The three eukaryotic RNA polymerases are complex multisubunit enzymes that play a central role in the transcription of nuclear genes. This gene encodes an essential and highly conserved subunit of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Chromosome

Cytoband

q27.1

Chromosome location (bp)

184361718 - 184368596

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163882 (version 78.38)

Entrez gene

5437

UniProt

P52434 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

POLR2H-001

ENSP00000392913
ENST00000456318

P52434
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P52434 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC3
C9JLU1 [Target identity:98%; Query identity:100%]
DNA-directed RNA polymerases I, II, and III subunit RPABC3 {ECO:0000313|Ensembl:ENSP00000409065}

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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000398 [mRNA splicing, via spliceosome]
GO:0001054 [RNA polymerase I activity]
GO:0001055 [RNA polymerase II activity]
GO:0001056 [RNA polymerase III activity]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0005666 [DNA-directed RNA polymerase III complex]
GO:0005736 [DNA-directed RNA polymerase I complex]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0006385 [transcription elongation from RNA polymerase III promoter]
GO:0006386 [termination of RNA polymerase III transcription]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032481 [positive regulation of type I interferon production]
GO:0045087 [innate immune response]
GO:0050434 [positive regulation of viral transcription]

150

17.1

POLR2H-002

ENSP00000403728
ENST00000412877

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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

1.4

POLR2H-003

ENSP00000398622
ENST00000438240

P52434
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P52434 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC3

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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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114

POLR2H-005

ENSP00000409065
ENST00000455712

C9JLU1
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C9JLU1 [Target identity:99%; Query identity:100%]
DNA-directed RNA polymerases I, II, and III subunit RPABC3 {ECO:0000313|Ensembl:ENSP00000409065}

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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0006351 [transcription, DNA-templated]

149

POLR2H-006

ENSP00000411883
ENST00000430783

P52434
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P52434 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC3

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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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122

13.8

POLR2H-007

ENSP00000393773
ENST00000443489

P52434
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P52434 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC3

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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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9.7

POLR2H-008

ENSP00000399882
ENST00000452961

P52434
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P52434 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC3

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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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114

POLR2H-009

ENSP00000415536
ENST00000429568

P52434
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P52434 [Direct mapping]
DNA-directed RNA polymerases I, II, and III subunit RPABC3

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SCAMPI predicted membrane proteins
THUMBUP predicted membrane proteins
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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175

19.8

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.