NKX6-1

GENERAL INFORMATION

? »

Gene name

NKX6-1

Gene description

NK6 homeobox 1

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Tissue enhanced (esophagus)
GTEx:Group enriched (esophagus, pancreas, testis, thyroid gland)

Protein evidence

Evidence at protein level

Protein localization

Selective nuclear expression in islets of Langerhans.

ANTIBODY RELIABILITY

? »

Data reliability
description

Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining.

Data reliability

Supportive based on 2 antibodies.
HPA036774 , CAB070169
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Tissue enhanced (esophagus)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (esophagus, pancreas, testis, thyroid gland)

Organ

Expression



GENE INFORMATION

? »

Gene name

NKX6-1 (HGNC Symbol)

Synonyms

Nkx6.1, NKX6A

Description

NK6 homeobox 1 (HGNC Symbol)

Entrez gene summary

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008]

Chromosome

4

Cytoband

q21.23

Chromosome location (bp)

84491987 - 84498450

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163623 (version 78.38)

Entrez gene

4825

UniProt

P78426 (UniProt - Evidence at transcript level)

neXtProt

NX_P78426

Antibodypedia

NKX6-1 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000295886
 
ENST00000515820
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NKX6-1-001 ENSP00000295886
ENST00000295886
P78426
Show all »
Show » Show » 367 37.8 No 0
NKX6-1-002 ENSP00000449761
ENST00000515820
F8VWZ9
Show all »
Show » Show » 93 10.5 No 0