EOMES

GENERAL INFORMATION

? »

Gene name

EOMES

Gene description

Eomesodermin

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Tissue enhanced (lymph node, spleen)
GTEx:Group enriched (cerebellum, spleen)

Protein evidence

Evidence at protein level

Protein localization

Most of the normal cells showed weak to moderate cytoplasmic immunoreactivity. Strong staining was observed in subsets of renal tubules and cardiac myocytes. Subsets of cells in lymphoid tissues showed moderate nuclear positivity. The liver, superficial squamous epithelia and Purkinje cells of cerebellum were negative.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA028896
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Tissue enhanced (lymph node, spleen)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebellum, spleen)

Organ

Expression



GENE INFORMATION

? »

Gene name

EOMES (HGNC Symbol)

Synonyms

TBR2

Description

Eomesodermin (HGNC Symbol)

Entrez gene summary

This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Chromosome

3

Cytoband

p24.1

Chromosome location (bp)

27715949 - 27722711

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163508 (version 78.38)

Entrez gene

8320

UniProt

O95936 (UniProt - Evidence at protein level)

neXtProt

NX_O95936

Antibodypedia

EOMES antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000295743
 
ENST00000449599
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EOMES-001 ENSP00000295743
ENST00000295743
O95936
Show all »
Show » Show » 686 72.7 No 0
EOMES-002 ENSP00000388620
ENST00000449599
O95936
Show all »
Show » Show » 705 74.9 No 0