ALPP

GENE INFORMATION

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Gene name

ALPP

Synonyms

Description

Alkaline phosphatase, placental (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]

Chromosome

2

Cytoband

q37.1

Chromosome location (bp)

232378534 - 232382889

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163283 (version 78.38)

Entrez gene

250

UniProt

P05187 (UniProt - Evidence at protein level)

neXtProt

NX_P05187

Antibodypedia

ALPP antibodies
 

PROTEIN VIEW

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ALPP-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALPP-001 ENSP00000375881
ENST00000392027
P05187
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