Tissue expression of ALOX15 - Summary - The Human Protein Atlas

GENERAL INFORMATION

? »

Protein class

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Predicted localization

Protein localization predicted from several bioinformatic algorithms. More info...

Number of transcripts

Number of protein-coding transcribed from this gene as defined by Ensembl.

Gene name

ALOX15

Gene description

Arachidonate 15-lipoxygenase

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

ANTIBODY RELIABILITY

? »

Data reliability description

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable.

Data reliability

Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 3 antibodies.
HPA013859 , CAB004962 , CAB004963

GENE INFORMATION

? »

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

ALOX15 (HGNC Symbol)

Synonyms

15-LOX-1

Description

Arachidonate 15-lipoxygenase (HGNC Symbol)

Entrez gene summary

Chromosome

Cytoband

p13.2

Chromosome location (bp)

4630902 - 4642294

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000161905 (version 78.38)

Entrez gene

246

UniProt

P16050 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALOX15-001

ENSP00000458832
ENST00000570836

P16050
Show all » « Hide

P16050 [Direct mapping]
Arachidonate 15-lipoxygenase
D3DTK1 [Target identity:61%; Query identity:100%]
Arachidonate 15-lipoxygenase, isoform CRA_a {ECO:0000313|EMBL:EAW90428.1}
I3L175 [Target identity:16%; Query identity:100%]
Arachidonate 15-lipoxygenase {ECO:0000313|Ensembl:ENSP00000458630}

Show » « Hide

Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001503 [ossification]
GO:0002820 [negative regulation of adaptive immune response]
GO:0004052 [arachidonate 12-lipoxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006691 [leukotriene metabolic process]
GO:0006954 [inflammatory response]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0016020 [membrane]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0019369 [arachidonic acid metabolic process]
GO:0019372 [lipoxygenase pathway]
GO:0030282 [bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035358 [regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0035963 [cellular response to interleukin-13]
GO:0042060 [wound healing]
GO:0043277 [apoptotic cell clearance]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0047977 [hepoxilin-epoxide hydrolase activity]
GO:0050473 [arachidonate 15-lipoxygenase activity]
GO:0051120 [hepoxilin A3 synthase activity]
GO:0051122 [hepoxilin biosynthetic process]
GO:0055114 [oxidation-reduction process]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071277 [cellular response to calcium ion]
GO:0097260 [eoxin A4 synthase activity]
GO:1901074 [regulation of engulfment of apoptotic cell]
GO:2001303 [lipoxin A4 biosynthetic process]

662

74.8

ALOX15-002

ENSP00000460483
ENST00000574640

P16050
Show all » « Hide

P16050 [Direct mapping]
Arachidonate 15-lipoxygenase
D3DTK1 [Target identity:65%; Query identity:100%]
Arachidonate 15-lipoxygenase, isoform CRA_a {ECO:0000313|EMBL:EAW90428.1}

Show » « Hide

GO:0001503 [ossification]
GO:0002820 [negative regulation of adaptive immune response]
GO:0004052 [arachidonate 12-lipoxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006691 [leukotriene metabolic process]
GO:0006954 [inflammatory response]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0016020 [membrane]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0019369 [arachidonic acid metabolic process]
GO:0019372 [lipoxygenase pathway]
GO:0030282 [bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035358 [regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0035963 [cellular response to interleukin-13]
GO:0042060 [wound healing]
GO:0043277 [apoptotic cell clearance]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050473 [arachidonate 15-lipoxygenase activity]
GO:0051122 [hepoxilin biosynthetic process]
GO:0055114 [oxidation-reduction process]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071277 [cellular response to calcium ion]
GO:0097260 [eoxin A4 synthase activity]
GO:1901074 [regulation of engulfment of apoptotic cell]
GO:2001303 [lipoxin A4 biosynthetic process]

623

70.1

ALOX15-005

ENSP00000460430
ENST00000572265

Show » « Hide

Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

0.3

ALOX15-008

ENSP00000458630
ENST00000576394

I3L175
Show all » « Hide

I3L175 [Target identity:100%; Query identity:100%]
Arachidonate 15-lipoxygenase {ECO:0000313|Ensembl:ENSP00000458630}

Show » « Hide

Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0055114 [oxidation-reduction process]

109

12.3

ALOX15-201

ENSP00000293761
ENST00000293761

P16050
Show all » « Hide

Show » « Hide

GO:0001503 [ossification]
GO:0002820 [negative regulation of adaptive immune response]
GO:0004052 [arachidonate 12-lipoxygenase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006691 [leukotriene metabolic process]
GO:0006954 [inflammatory response]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0016020 [membrane]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0019369 [arachidonic acid metabolic process]
GO:0019372 [lipoxygenase pathway]
GO:0030282 [bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035358 [regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0035963 [cellular response to interleukin-13]
GO:0042060 [wound healing]
GO:0043277 [apoptotic cell clearance]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050473 [arachidonate 15-lipoxygenase activity]
GO:0051122 [hepoxilin biosynthetic process]
GO:0055114 [oxidation-reduction process]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071277 [cellular response to calcium ion]
GO:0097260 [eoxin A4 synthase activity]
GO:1901074 [regulation of engulfment of apoptotic cell]
GO:2001303 [lipoxin A4 biosynthetic process]

662

74.8

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.