NPR2

GENE INFORMATION

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Gene name

NPR2 (HGNC Symbol)

Synonyms

AMDM, ANPb, ANPRB, GUCY2B, NPRB

Description

Natriuretic peptide receptor 2 (HGNC Symbol)

Entrez gene summary

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

p13.3

Chromosome location (bp)

35792154 - 35809732

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159899 (version 78.38)

Entrez gene

4882

UniProt

P20594 (UniProt - Evidence at protein level)

neXtProt

NX_P20594

Antibodypedia

NPR2 antibodies
 

PROTEIN VIEW

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NPR2-001
 
NPR2-003
 
NPR2-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NPR2-001 ENSP00000341083
ENST00000342694
P20594
Show all »
Show » Show » 1047 117 Yes 1
NPR2-003 ENSP00000399204
ENST00000421267
Show » Show » 275 30.9 No 0
NPR2-005 ENSP00000393029
ENST00000447210
H7C056
Show all »
Show » Show » 164 19 No 0