Tissue expression of FZD7 - Summary - The Human Protein Atlas

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FZD7

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS

GENE/PROTEIN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	FZD7
Gene description	Frizzled class receptor 7
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Mixed
GTEx:	Mixed

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability	Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW ? »
Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation. For genes with available protein data for which a knowledge-based annotation could not be performed, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Mixed

Organ

Expression

GTEx dataset

RNA tissue category:

Mixed

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	FZD7 (HGNC Symbol)
Synonyms	FzE3
Description	Frizzled class receptor 7 (HGNC Symbol)
Entrez gene summary	Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q33.1
Chromosome location (bp)	202034587 - 202038445
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000155760 (version 78.38)
Entrez gene	8324
UniProt	O75084 (UniProt - Evidence at protein level)
neXtProt	NX_O75084
Antibodypedia	FZD7 antibodies

PROTEIN BROWSER

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ENST00000286201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
FZD7-001	ENSP00000286201 ENST00000286201	O75084 Show all » « Hide O75084 [Direct mapping] Frizzled-7	Show » « Hide G-protein coupled receptors GPCRs excl olfactory receptors Family fz/smo receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001944 [vasculature development] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005109 [frizzled binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0007166 [cell surface receptor signaling pathway] GO:0007199 [G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger] GO:0007223 [Wnt signaling pathway, calcium modulating pathway] GO:0007409 [axonogenesis] GO:0007420 [brain development] GO:0008406 [gonad development] GO:0010812 [negative regulation of cell-substrate adhesion] GO:0014834 [skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017147 [Wnt-protein binding] GO:0019827 [stem cell maintenance] GO:0030165 [PDZ domain binding] GO:0030182 [neuron differentiation] GO:0032589 [neuron projection membrane] GO:0033077 [T cell differentiation in thymus] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0035412 [regulation of catenin import into nucleus] GO:0035567 [non-canonical Wnt signaling pathway] GO:0038031 [non-canonical Wnt signaling pathway via JNK cascade] GO:0042327 [positive regulation of phosphorylation] GO:0042666 [negative regulation of ectodermal cell fate specification] GO:0042813 [Wnt-activated receptor activity] GO:0045177 [apical part of cell] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046330 [positive regulation of JNK cascade] GO:0048103 [somatic stem cell division] GO:0060054 [positive regulation of epithelial cell proliferation involved in wound healing] GO:0060070 [canonical Wnt signaling pathway] GO:0060231 [mesenchymal to epithelial transition] GO:0071300 [cellular response to retinoic acid]	574	63.6	Yes	7

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx