ANGPT1

GENERAL INFORMATION

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Gene name

ANGPT1

Gene description

Angiopoietin 1

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA018793 , HPA018816 , CAB017815
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression



GENE INFORMATION

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Gene name

ANGPT1 (HGNC Symbol)

Synonyms

Ang1, KIAA0003

Description

Angiopoietin 1 (HGNC Symbol)

Entrez gene summary

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

Chromosome

8

Cytoband

q23.1

Chromosome location (bp)

107249482 - 107498055

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000154188 (version 78.38)

Entrez gene

284

UniProt

Q15389 (UniProt - Evidence at protein level)

neXtProt

NX_Q15389

Antibodypedia

ANGPT1 antibodies


PROTEIN BROWSER

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ENST00000297450
 
ENST00000517746
 
ENST00000520033
 
ENST00000520052
 
ENST00000520734
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ANGPT1-001 ENSP00000428340
ENST00000517746
Q15389
Show all »
Show » Show » 498 57.5 Yes 0
ANGPT1-002 ENSP00000430750
ENST00000520734
B4DTQ9
Show all »
Show » Show » 298 34.3 No 0
ANGPT1-003 ENSP00000297450
ENST00000297450
Q15389
Show all »
Show » Show » 497 57.5 Yes 0
ANGPT1-006 ENSP00000428908
ENST00000520033
E5RFF4
Show all »
Show » Show » 30 3.3 No 0
ANGPT1-009 ENSP00000429349
ENST00000520052
E7ERK4
Show all »
Show » Show » 297 34.3 No 0