ADM

GENERAL INFORMATION

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Gene name

ADM

Gene description

Adrenomedullin

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Subsets of cells in bone marrow and the red pulp of spleen as well as gastric parietal and chief cells showed strong cytoplasmic staining. Moderate positivity was observed in male genitalia, endometrium, thyroid and renal tubules. Remaining normal tissues were generally negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB016075
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ADM (HGNC Symbol)

Synonyms

AM

Description

Adrenomedullin (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

10304680 - 10307397

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000148926 (version 78.38)

Entrez gene

133

UniProt

P35318 (UniProt - Evidence at protein level)

neXtProt

NX_P35318

Antibodypedia

ADM antibodies


PROTEIN BROWSER

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ENST00000278175
 
ENST00000524948
 
ENST00000525063
 
ENST00000526492
 
ENST00000528544
 
ENST00000528655
 
ENST00000530439
 
ENST00000534464
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADM-001 ENSP00000278175
ENST00000278175
P35318
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Show » Show » 185 20.4 Yes 0
ADM-002 ENSP00000436607
ENST00000528655
P35318
Show all »
Show » Show » 185 20.4 Yes 0
ADM-003 ENSP00000431438
ENST00000534464
E9PL83
Show all »
Show » Show » 138 15.1 No 0
ADM-004 ENSP00000436837
ENST00000530439
E9PQE6
Show all »
Show » Show » 117 12.9 No 0
ADM-005 ENSP00000433062
ENST00000524948
E9PML4
Show all »
Show » Show » 83 9.2 Yes 0
ADM-006 ENSP00000434354
ENST00000526492
E9PQT2
Show all »
Show » Show » 139 15.2 Yes 0
ADM-007 ENSP00000435124
ENST00000525063
P35318
Show all »
Show » Show » 185 20.4 Yes 0
ADM-008 ENSP00000434749
ENST00000528544
E9PML4
Show all »
Show » Show » 83 9.2 Yes 0