Tissue expression of NFIB - Summary - The Human Protein Atlas

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NFIB

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TISSUE

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SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	NFIB
Gene description	Nuclear factor I/B
Protein class	Cancer-related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General nuclear expression.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Data reliability	Supportive based on 1 antibody. HPA003956
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Mixed

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	NFIB (HGNC Symbol)
Synonyms	NFI-RED, NFIB2, NFIB3
Description	Nuclear factor I/B (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband
Chromosome location (bp)	14081843 - 14398983
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147862 (version 78.38)
Entrez gene	4781
UniProt	O00712 (UniProt - Evidence at protein level)
neXtProt	NX_O00712
Antibodypedia	NFIB antibodies

PROTEIN BROWSER

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ENST00000380921		ENST00000380924		ENST00000380934		ENST00000380953		ENST00000380959		ENST00000397575		ENST00000397579		ENST00000397581		ENST00000493697		ENST00000543693		ENST00000606230		ENST00000622101		ENST00000622520

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
NFIB-001	ENSP00000370346 ENST00000380959	O00712 Show all » « Hide O00712 [Direct mapping] Nuclear factor 1 B-type Q5VW28 [Target identity:100%; Query identity:100%] Nuclear factor 1 {ECO:0000256\|RuleBase:RU000690} Q5VW31 [Target identity:40%; Query identity:100%] Nuclear factor 1 B-type {ECO:0000313\|Ensembl:ENSP00000370311}	Show » « Hide Predicted intracellular proteins Transcription factors beta-Hairpin exposed by an alpha/beta-scaffold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000981 [sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001106 [RNA polymerase II transcription corepressor activity] GO:0002062 [chondrocyte differentiation] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006260 [DNA replication] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0010001 [glial cell differentiation] GO:0021740 [principal sensory nucleus of trigeminal nerve development] GO:0021960 [anterior commissure morphogenesis] GO:0043392 [negative regulation of DNA binding] GO:0044300 [cerebellar mossy fiber] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060486 [Clara cell differentiation] GO:0060509 [Type I pneumocyte differentiation] GO:0060510 [Type II pneumocyte differentiation] GO:0061141 [lung ciliated cell differentiation] GO:0071679 [commissural neuron axon guidance] GO:2000791 [negative regulation of mesenchymal cell proliferation involved in lung development] GO:2000795 [negative regulation of epithelial cell proliferation involved in lung morphogenesis]	420	47.4	No	0
NFIB-002	ENSP00000380709 ENST00000397579	Q5VW27 Show all » « Hide Q5VW27 [Target identity:100%; Query identity:100%] Nuclear factor 1 {ECO:0000256\|RuleBase:RU000690}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006260 [DNA replication] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated]	487	54.9	No	0
NFIB-003	ENSP00000380711 ENST00000397581	Q5VW26 Show all » « Hide Q5VW26 [Target identity:100%; Query identity:100%] Nuclear factor 1 {ECO:0000256\|RuleBase:RU000690}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006260 [DNA replication] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated]	570	63.4	No	0
NFIB-004	ENSP00000380705 ENST00000397575	Q5VW30 Show all » « Hide Q5VW30 [Target identity:100%; Query identity:100%] Nuclear factor 1 {ECO:0000256\|RuleBase:RU000690}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006260 [DNA replication] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated]	561	62.6	No	0
NFIB-005	ENSP00000370340 ENST00000380953	O00712 Show all » « Hide O00712 [Direct mapping] Nuclear factor 1 B-type	Show » « Hide Predicted intracellular proteins Transcription factors beta-Hairpin exposed by an alpha/beta-scaffold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000981 [sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001106 [RNA polymerase II transcription corepressor activity] GO:0002062 [chondrocyte differentiation] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006260 [DNA replication] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008285 [negative regulation of cell proliferation] GO:0010001 [glial cell differentiation] GO:0021740 [principal sensory nucleus of trigeminal nerve development] GO:0021960 [anterior commissure morphogenesis] GO:0030324 [lung development] GO:0030900 [forebrain development] GO:0030902 [hindbrain development] GO:0043392 [negative regulation of DNA binding] GO:0044300 [cerebellar mossy fiber] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060486 [Clara cell differentiation] GO:0060509 [Type I pneumocyte differentiation] GO:0060510 [Type II pneumocyte differentiation] GO:0061141 [lung ciliated cell differentiation] GO:0071679 [commissural neuron axon guidance] GO:2000791 [negative regulation of mesenchymal cell proliferation involved in lung development] GO:2000795 [negative regulation of epithelial cell proliferation involved in lung morphogenesis]	494	55.2	No	0
NFIB-006	ENSP00000370308 ENST00000380921	Q5W0Y9 Show all » « Hide Q5W0Y9 [Target identity:100%; Query identity:100%] Nuclear factor 1 B-type {ECO:0000313\|Ensembl:ENSP00000370308}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006260 [DNA replication] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated]	200	23.6	No	0
NFIB-007	ENSP00000475362 ENST00000493697	U3KPY9 Show all » « Hide U3KPY9 [Target identity:99%; Query identity:100%] Nuclear factor 1 B-type {ECO:0000313\|Ensembl:ENSP00000475362}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006260 [DNA replication] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated]	167	19.7	No	0
NFIB-008	ENSP00000370311 ENST00000380924	Q5VW31 Show all » « Hide Q5VW31 [Target identity:100%; Query identity:100%] Nuclear factor 1 B-type {ECO:0000313\|Ensembl:ENSP00000370311}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006260 [DNA replication] GO:0006355 [regulation of transcription, DNA-templated]	168	18.4	No	0
NFIB-009	ENSP00000475813 ENST00000606230	U3KQE8 Show all » « Hide U3KQE8 [Target identity:100%; Query identity:100%] Nuclear factor 1 B-type {ECO:0000313\|Ensembl:ENSP00000475813}	Show » « Hide Phobius predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006260 [DNA replication] GO:0006355 [regulation of transcription, DNA-templated]	59	7.2	No	0
NFIB-201	ENSP00000370321 ENST00000380934	Q5VW31 Show all » « Hide Q5VW31 [Target identity:37%; Query identity:100%] Nuclear factor 1 B-type {ECO:0000313\|Ensembl:ENSP00000370311}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006260 [DNA replication] GO:0006355 [regulation of transcription, DNA-templated]	446	50.3	No	0
NFIB-202	ENSP00000442888 ENST00000543693	O00712 Show all » « Hide O00712 [Direct mapping] Nuclear factor 1 B-type	Show » « Hide Predicted intracellular proteins Transcription factors beta-Hairpin exposed by an alpha/beta-scaffold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000981 [sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001106 [RNA polymerase II transcription corepressor activity] GO:0002062 [chondrocyte differentiation] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006260 [DNA replication] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0010001 [glial cell differentiation] GO:0021740 [principal sensory nucleus of trigeminal nerve development] GO:0021960 [anterior commissure morphogenesis] GO:0043392 [negative regulation of DNA binding] GO:0044300 [cerebellar mossy fiber] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060486 [Clara cell differentiation] GO:0060509 [Type I pneumocyte differentiation] GO:0060510 [Type II pneumocyte differentiation] GO:0061141 [lung ciliated cell differentiation] GO:0071679 [commissural neuron axon guidance] GO:2000791 [negative regulation of mesenchymal cell proliferation involved in lung development] GO:2000795 [negative regulation of epithelial cell proliferation involved in lung morphogenesis]	309	33.5	No	0
NFIB-203	ENSP00000480557 ENST00000622101	O00712 Show all » « Hide O00712 [Direct mapping] Nuclear factor 1 B-type	Show » « Hide Predicted intracellular proteins Transcription factors beta-Hairpin exposed by an alpha/beta-scaffold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000981 [sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0001106 [RNA polymerase II transcription corepressor activity] GO:0002062 [chondrocyte differentiation] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006260 [DNA replication] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0010001 [glial cell differentiation] GO:0021740 [principal sensory nucleus of trigeminal nerve development] GO:0021960 [anterior commissure morphogenesis] GO:0043392 [negative regulation of DNA binding] GO:0044300 [cerebellar mossy fiber] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060486 [Clara cell differentiation] GO:0060509 [Type I pneumocyte differentiation] GO:0060510 [Type II pneumocyte differentiation] GO:0061141 [lung ciliated cell differentiation] GO:0071679 [commissural neuron axon guidance] GO:2000791 [negative regulation of mesenchymal cell proliferation involved in lung development] GO:2000795 [negative regulation of epithelial cell proliferation involved in lung morphogenesis]	309	33.5	No	0
NFIB-204	ENSP00000481181 ENST00000622520		Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006260 [DNA replication] GO:0006355 [regulation of transcription, DNA-templated]	188	22.3	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.