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GENERAL INFORMATION
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Protein class
Protein class the gene product belongs to according to selected gene lists. List of protein classes.
Predicted localization
Protein localization predicted from several bioinformatic algorithms. More info...
Number of transcripts
Number of protein-coding transcribed from this gene as defined by Ensembl.
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Gene name |
AGTR1 |
Gene description |
Angiotensin II receptor, type 1 |
Protein class |
Disease related genes
FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins
Transporters |
Predicted localization |
Membrane |
Number of transcripts |
8 |
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HUMAN PROTEIN ATLAS INFORMATION
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RNA tissue category
The RNA tissue category is based on mRNA expression levels in 32 different tissues ( RNA assay description).
The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, not detected, and mixed.
RNA tissue category is calculated separately both for internally generated Human Protein Atlas (HPA) RNA-seq data, as
well as RNA-seq data from the Genotype-Tissue Expression ( GTEx) consortium.
Protein evidence
Protein evidence scores are generated from several independent sources
and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence or iv) not available.
Protein localization
A summary of the overall protein expression pattern across the analyzed tissues. The summary is based on knowledge-based
annotation ( Annotation description). For genes pending
knowledge-based annotation, the protein localization refers to the antibody staining pattern.
"RNA-based expert annotation gave inconconclusive results" is shown for genes analyzed with a knowledge-based approach where
available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with
immunohistochemistry-data to yield a reliable estimation of the protein expression profile.
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RNA tissue category |
| HPA: | Group enriched (adipose tissue, adrenal gland, liver, placenta) |
| GTEx: | Tissue enhanced (adipose tissue) |
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Protein evidence |
Evidence at protein level |
Protein localization |
Cytoplasmic expression in adipocytes and endothelial cells. |
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ANTIBODY RELIABILITY
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Data reliability description
Standardized explanatory sentences with additional information required for full understanding of the
knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based
annotation, indicated by "Pending RNA-based expert annotation", when applicable.
Data reliability
Data reliability score ( score description), divided into supportive (premium)
or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several
antibodies with RNA-seq data and available gene/protein characterization data.
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Data reliability
description |
Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images. |
Data reliability |
Supportive based on 1 antibody.
HPA003596
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PROTEIN EXPRESSION OVERVIEW
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Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting
of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a
selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in
detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation could not be performed, no protein
expression data is displayed in the protein expression data overview, however, all immunohistochemical images are
still available and the annotation data can be found under Primary data.
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GENE INFORMATION
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Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
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Gene name |
AGTR1 (HGNC Symbol) |
Synonyms |
AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT2R1, AT2R1A, AT2R1B, HAT1R |
Description |
Angiotensin II receptor, type 1 (HGNC Symbol) |
Entrez gene summary |
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012] |
Chromosome |
3 |
Cytoband |
q24 |
Chromosome location (bp) |
148697784 - 148743008 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000144891 (version 78.38) |
Entrez gene |
185 |
UniProt |
P30556 (UniProt - Evidence at protein level) |
neXtProt |
NX_P30556 |
Antibodypedia |
AGTR1 antibodies |
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PROTEIN BROWSER
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The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The
tabs at the top of the protein view section can be used to switch between the different splice variants to which
an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green
bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is
displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues
(HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius (turquoise)
and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow
and InterPro regions in green. Common (purple) and
unique (grey) regions between different splice variants of the gene are also displayed
( read more), and at the
bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this
gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary
for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the
protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are
listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a
majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0 and
Phobius) and the number of predicted transmembrane region(s)
(according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length
(aa) |
Molecular mass
(kDa) |
Signal peptide
(predicted) |
Transmembrane regions
(predicted)
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| AGTR1-001 |
ENSP00000273430
ENST00000349243
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P30556
Show all »
« Hide
P30556 [Direct mapping]Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%]Angiotensin II receptor, type 1 {ECO:0000313|EMBL:AAR03503.1}; Angiotensin II receptor, type 1, isoform CRA_b {ECO:0000313|EMBL:EAW78906.1}; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA {ECO:0000313|EMBL:BAF84230.1}
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Show »
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Transporters
G-protein coupled receptors
GPCRs excl olfactory receptors
Predicted membrane proteins
Prediction method-based
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
# TM segments-based
7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
Small molecule drugs
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Show »
« Hide
GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004930 [G-protein coupled receptor activity] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0038166 [angiotensin-activated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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359 |
41.1 |
No |
7 |
| AGTR1-002 |
ENSP00000419422
ENST00000497524
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P30556
Show all »
« Hide
P30556 [Direct mapping]Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%]Angiotensin II receptor, type 1 {ECO:0000313|EMBL:AAR03503.1}; Angiotensin II receptor, type 1, isoform CRA_b {ECO:0000313|EMBL:EAW78906.1}; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA {ECO:0000313|EMBL:BAF84230.1}
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Show »
« Hide
Transporters
G-protein coupled receptors
GPCRs excl olfactory receptors
Predicted membrane proteins
Prediction method-based
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
# TM segments-based
7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
Small molecule drugs
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Show »
« Hide
GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004930 [G-protein coupled receptor activity] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0038166 [angiotensin-activated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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359 |
41.1 |
No |
7 |
| AGTR1-003 |
ENSP00000385612
ENST00000404754
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P30556
Show all »
« Hide
P30556 [Direct mapping]Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%]Angiotensin II receptor, type 1 {ECO:0000313|EMBL:AAR03503.1}; Angiotensin II receptor, type 1, isoform CRA_b {ECO:0000313|EMBL:EAW78906.1}; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA {ECO:0000313|EMBL:BAF84230.1}
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Show »
« Hide
Transporters
G-protein coupled receptors
GPCRs excl olfactory receptors
Predicted membrane proteins
Prediction method-based
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
# TM segments-based
7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
Small molecule drugs
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Show »
« Hide
GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004930 [G-protein coupled receptor activity] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0038166 [angiotensin-activated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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359 |
41.1 |
No |
7 |
| AGTR1-005 |
ENSP00000419783
ENST00000475347
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P30556
Show all »
« Hide
P30556 [Direct mapping]Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%]Angiotensin II receptor, type 1 {ECO:0000313|EMBL:AAR03503.1}; Angiotensin II receptor, type 1, isoform CRA_b {ECO:0000313|EMBL:EAW78906.1}; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA {ECO:0000313|EMBL:BAF84230.1}
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Show »
« Hide
Transporters
G-protein coupled receptors
GPCRs excl olfactory receptors
Predicted membrane proteins
Prediction method-based
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
# TM segments-based
7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
Small molecule drugs
|
Show »
« Hide
GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004930 [G-protein coupled receptor activity] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0038166 [angiotensin-activated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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359 |
41.1 |
No |
7 |
| AGTR1-006 |
ENSP00000418084
ENST00000474935
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P30556
Show all »
« Hide
P30556 [Direct mapping]Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%]Angiotensin II receptor, type 1 {ECO:0000313|EMBL:AAR03503.1}; Angiotensin II receptor, type 1, isoform CRA_b {ECO:0000313|EMBL:EAW78906.1}; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA {ECO:0000313|EMBL:BAF84230.1}
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Show »
« Hide
Transporters
G-protein coupled receptors
GPCRs excl olfactory receptors
Predicted membrane proteins
Prediction method-based
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
# TM segments-based
7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
Small molecule drugs
|
Show »
« Hide
GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004930 [G-protein coupled receptor activity] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0038166 [angiotensin-activated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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359 |
41.1 |
No |
7 |
| AGTR1-007 |
ENSP00000418851
ENST00000461609
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P30556
Show all »
« Hide
P30556 [Direct mapping]Type-1 angiotensin II receptor Q53YY0 [Target identity:100%; Query identity:100%]Angiotensin II receptor, type 1 {ECO:0000313|EMBL:AAR03503.1}; Angiotensin II receptor, type 1, isoform CRA_b {ECO:0000313|EMBL:EAW78906.1}; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA {ECO:0000313|EMBL:BAF84230.1}
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Show »
« Hide
Transporters
G-protein coupled receptors
GPCRs excl olfactory receptors
Predicted membrane proteins
Prediction method-based
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
# TM segments-based
7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
Small molecule drugs
|
Show »
« Hide
GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004930 [G-protein coupled receptor activity] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0038166 [angiotensin-activated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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359 |
41.1 |
No |
7 |
| AGTR1-201 |
ENSP00000385641
ENST00000402260
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Q53YY0
Show all »
« Hide
Q53YY0 [Target identity:92%; Query identity:100%]Angiotensin II receptor, type 1 {ECO:0000313|EMBL:AAR03503.1}; Angiotensin II receptor, type 1, isoform CRA_b {ECO:0000313|EMBL:EAW78906.1}; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA {ECO:0000313|EMBL:BAF84230.1}
|
Show »
« Hide
Predicted membrane proteins
Prediction method-based
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
# TM segments-based
7TM proteins predicted by MDM
|
Show »
« Hide
GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004930 [G-protein coupled receptor activity] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0038166 [angiotensin-activated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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388 |
44.2 |
No |
7 |
| AGTR1-202 |
ENSP00000398832
ENST00000418473
|
D3DNG8
Show all »
« Hide
D3DNG8 [Target identity:100%; Query identity:100%]Angiotensin II receptor, type 1, isoform CRA_a {ECO:0000313|EMBL:EAW78909.1} Q53YY0 [Target identity:91%; Query identity:100%]Angiotensin II receptor, type 1 {ECO:0000313|EMBL:AAR03503.1}; Angiotensin II receptor, type 1, isoform CRA_b {ECO:0000313|EMBL:EAW78906.1}; cDNA FLJ75705, highly similar to Homo sapiens angiotensin II receptor, type 1 (AGTR1), transcript variant 1, mRNA {ECO:0000313|EMBL:BAF84230.1} Q13063 [Target identity:10%; Query identity:100%]Type 1 angiotensin II receptor isoform {ECO:0000313|EMBL:AAB35647.1}
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Show »
« Hide
Predicted membrane proteins
Prediction method-based
Membrane proteins predicted by MDM
MEMSAT3 predicted membrane proteins
MEMSAT-SVM predicted membrane proteins
Phobius predicted membrane proteins
SCAMPI predicted membrane proteins
SPOCTOPUS predicted membrane proteins
THUMBUP predicted membrane proteins
TMHMM predicted membrane proteins
GPCRHMM predicted membrane proteins
# TM segments-based
7TM proteins predicted by MDM
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GO:0001558 [regulation of cell growth] GO:0001596 [angiotensin type I receptor activity] GO:0001822 [kidney development] GO:0002018 [renin-angiotensin regulation of aldosterone production] GO:0002034 [regulation of blood vessel size by renin-angiotensin] GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin] GO:0004930 [G-protein coupled receptor activity] GO:0004945 [angiotensin type II receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007266 [Rho protein signal transduction] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010873 [positive regulation of cholesterol esterification] GO:0016021 [integral component of membrane] GO:0019229 [regulation of vasoconstriction] GO:0019722 [calcium-mediated signaling] GO:0031711 [bradykinin receptor binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032430 [positive regulation of phospholipase A2 activity] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034374 [low-density lipoprotein particle remodeling] GO:0035813 [regulation of renal sodium excretion] GO:0038166 [angiotensin-activated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042312 [regulation of vasodilation] GO:0046982 [protein heterodimerization activity] GO:0050727 [regulation of inflammatory response] GO:0050729 [positive regulation of inflammatory response] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway] GO:0060326 [cell chemotaxis] GO:0086097 [phospholipase C-activating angiotensin-activated signaling pathway] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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394 |
44.9 |
No |
7 |
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