CDH13

GENERAL INFORMATION

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Gene name

CDH13

Gene description

Cadherin 13

Protein class

Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Distinct membranous and cytoplasmic expression in muscle cells and renal glomeruli while basal cells in squamous showed cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA001380 , CAB025863
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

CDH13 (HGNC Symbol)

Synonyms

CDHH

Description

Cadherin 13 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]

Chromosome

16

Cytoband

q23.3

Chromosome location (bp)

82626803 - 83800640

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000140945 (version 78.38)

Entrez gene

1012

UniProt

P55290 (UniProt - Evidence at protein level)

neXtProt

NX_P55290

Antibodypedia

CDH13 antibodies


PROTEIN BROWSER

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ENST00000268613
 
ENST00000428848
 
ENST00000431540
 
ENST00000565636
 
ENST00000566620
 
ENST00000567109
 
ENST00000567445
 
ENST00000615627
 
ENST00000622885
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDH13-001 ENSP00000479395
ENST00000567109
P55290
Show all »
Show » Show » 713 78.3 Yes 0
CDH13-003 ENSP00000408632
ENST00000431540
P55290
Show all »
Show » Show » 190 21.1 Yes 0
CDH13-004 ENSP00000456491
ENST00000565636
P55290
Show all »
Show » Show » 175 19.7 Yes 0
CDH13-005 ENSP00000394557
ENST00000428848
P55290
Show all »
Show » Show » 674 73.8 Yes 0
CDH13-007 ENSP00000456297
ENST00000567445
H3BRL7
Show all »
Show » 67 7.6 Yes 0
CDH13-009 ENSP00000268613
ENST00000268613
P55290
Show all »
Show » Show » 760 83.4 No 0
CDH13-201 ENSP00000454435
ENST00000566620
Show » Show » 700 76.8 No 0
CDH13-202 ENSP00000482651
ENST00000615627
Show » Show » 353 38.4 No 0
CDH13-203 ENSP00000483719
ENST00000622885
Show » Show » 661 72.3 No 0