EGF

GENE INFORMATION

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Gene name

EGF

Synonyms

Description

Epidermal growth factor (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Chromosome

4

Cytoband

q25

Chromosome location (bp)

109912884 - 110012266

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138798 (version 78.38)

Entrez gene

1950

UniProt

P01133 (UniProt - Evidence at protein level)

neXtProt

NX_P01133

Antibodypedia

EGF antibodies
 

PROTEIN VIEW

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EGF-001
 
EGF-002
 
EGF-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EGF-001 ENSP00000265171
ENST00000265171
P01133
Show all »
Show » Show » 1207 134 Yes 1
EGF-002 ENSP00000424316
ENST00000509793
P01133
Show all »
Show » Show » 1165 129.3 Yes 1
EGF-003 ENSP00000421384
ENST00000503392
P01133
Show all »
Show » Show » 1166 129.7 Yes 1