BARD1

GENE INFORMATION

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Gene name

BARD1

Synonyms

Description

BRCA1 associated RING domain 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Chromosome

2

Cytoband

q35

Chromosome location (bp)

214725646 - 214809711

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138376 (version 78.38)

Entrez gene

580

UniProt

Q99728 (UniProt - Evidence at protein level)

neXtProt

NX_Q99728

Antibodypedia

BARD1 antibodies
 

PROTEIN VIEW

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BARD1-001
 
BARD1-004
 
BARD1-005
 
BARD1-201
 
BARD1-202
 
BARD1-203
 
BARD1-204
 
BARD1-205
 
BARD1-206
 
BARD1-207
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BARD1-001 ENSP00000260947
ENST00000260947
Q99728
Show all »
Show » Show » 777 86.6 No 0
BARD1-004 ENSP00000405020
ENST00000432456
Show » 44 5.3 No 0
BARD1-005 ENSP00000392245
ENST00000421162
C9IYG1
Show all »
Show » 216 24.4 No 0
BARD1-201 ENSP00000406752
ENST00000449967
Q99728
Show all »
Show » Show » 680 75.5 No 0
BARD1-202 ENSP00000483275
ENST00000613192
Show » 167 19.2 No 0
BARD1-203 ENSP00000484464
ENST00000613374
F6MDI1
Show all »
Show » 307 35.1 No 0
BARD1-204 ENSP00000484976
ENST00000613706
C9IYG1
Show all »
Show » 326 37.1 No 0
BARD1-205 ENSP00000480470
ENST00000617164
Q99728
Show all »
Show » Show » 758 84.6 No 0
BARD1-206 ENSP00000482293
ENST00000619009
Show » Show » 264 30.4 No 0
BARD1-207 ENSP00000481988
ENST00000620057
Q99728
Show all »
Show » Show » 127 14.4 No 0