HMGA1

GENE INFORMATION

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Gene name

HMGA1 (HGNC Symbol)

Synonyms

HMGIY

Description

High mobility group AT-hook 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.31

Chromosome location (bp)

34236873 - 34246231

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137309 (version 78.38)

Entrez gene

3159

UniProt

P17096 (UniProt - Evidence at protein level)

neXtProt

NX_P17096

Antibodypedia

HMGA1 antibodies
 

PROTEIN VIEW

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HMGA1-001
 
HMGA1-002
 
HMGA1-004
 
HMGA1-201
 
HMGA1-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HMGA1-001 ENSP00000288245
ENST00000347617
P17096
Show all »
Show » Show » 96 10.7 No 0
HMGA1-002 ENSP00000385693
ENST00000401473
P17096
Show all »
Show » Show » 96 10.7 No 0
HMGA1-004 ENSP00000308227
ENST00000311487
P17096
Show all »
Show » Show » 107 11.7 No 0
HMGA1-201 ENSP00000363230
ENST00000374116
P17096
Show all »
Show » Show » 96 10.7 No 0
HMGA1-202 ENSP00000399888
ENST00000447654
P17096
Show all »
Show » Show » 107 11.7 No 0