CCL21

GENERAL INFORMATION

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Gene name

CCL21

Gene description

Chemokine (C-C motif) ligand 21

Protein class

Cancer-related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lymph node, tonsil)
GTEx:Tissue enhanced (small intestine, thyroid gland)

Protein evidence

Evidence at protein level

Protein localization

Expression in a subset of vessels in lymph node.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA051210 , CAB005067
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lymph node, tonsil)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (small intestine, thyroid gland)

Organ

Expression



GENE INFORMATION

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Gene name

CCL21 (HGNC Symbol)

Synonyms

6Ckine, CKb9, ECL, exodus-2, SCYA21, SLC, TCA4

Description

Chemokine (C-C motif) ligand 21 (HGNC Symbol)

Entrez gene summary

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]

Chromosome

9

Cytoband

p13.3

Chromosome location (bp)

34709005 - 34710124

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137077 (version 78.38)

Entrez gene

6366

UniProt

O00585 (UniProt - Evidence at protein level)

neXtProt

NX_O00585

Antibodypedia

CCL21 antibodies


PROTEIN BROWSER

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ENST00000259607
 
ENST00000378792
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCL21-001 ENSP00000368069
ENST00000378792
Q5VZ73
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Show » Show » 124 13.6 Yes 0
CCL21-002 ENSP00000259607
ENST00000259607
O00585
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Show » Show » 134 14.6 Yes 0