MYC

GENERAL INFORMATION

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Gene name

MYC

Gene description

V-myc avian myelocytomatosis viral oncogene homolog

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear and nucleolar expression in essentially all cells except in glial- and stroma cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 3 antibodies.
HPA055893 , CAB000084 , CAB010307
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Cervix, uterine



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MYC (HGNC Symbol)

Synonyms

bHLHe39, c-Myc, MYCC

Description

V-myc avian myelocytomatosis viral oncogene homolog (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

q24.21

Chromosome location (bp)

127735434 - 127741434

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136997 (version 78.38)

Entrez gene

4609

UniProt

P01106 (UniProt - Evidence at protein level)

neXtProt

NX_P01106

Antibodypedia

MYC antibodies


PROTEIN BROWSER

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ENST00000259523
 
ENST00000377970
 
ENST00000517291
 
ENST00000520751
 
ENST00000524013
 
ENST00000613283
 
ENST00000621592
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MYC-001 ENSP00000478887
ENST00000621592
A0A024R9L7
Show all »
Show » Show » 454 50.5 No 0
MYC-002 ENSP00000259523
ENST00000259523
B3CJ65
Show all »
Show » Show » 257 27.8 No 0
MYC-003 ENSP00000429441
ENST00000517291
H0YBG3
Show all »
Show » Show » 184 20.5 No 0
MYC-004 ENSP00000430235
ENST00000524013
H0YBT0
Show all »
Show » Show » 453 50.4 No 0
MYC-005 ENSP00000430226
ENST00000520751
E5RGD7
Show all »
Show » 60 6.3 No 0
MYC-006 ENSP00000367207
ENST00000377970
P01106
Show all »
Show » Show » 439 48.8 No 0
MYC-201 ENSP00000479618
ENST00000613283
A0A024R9L7
Show all »
Show » Show » 454 50.5 No 0