Tissue expression of NR5A1 - Summary - The Human Protein Atlas

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NR5A1

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS

GENE/PROTEIN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	NR5A1
Gene description	Nuclear receptor subfamily 5, group A, member 1
Protein class	Disease related genes Nuclear receptors Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Group enriched (adrenal gland, ovary, spleen)
GTEx:	Group enriched (adrenal gland, ovary, spleen)

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability	Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW ? »
Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation. For genes with available protein data for which a knowledge-based annotation could not be performed, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Group enriched (adrenal gland, ovary, spleen)

Organ

Expression

GTEx dataset

RNA tissue category:

Group enriched (adrenal gland, ovary, spleen)

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	NR5A1 (HGNC Symbol)
Synonyms	AD4BP, ELP, FTZ1, FTZF1, SF-1
Description	Nuclear receptor subfamily 5, group A, member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q33.3
Chromosome location (bp)	124481236 - 124507430
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136931 (version 78.38)
Entrez gene	2516
UniProt	Q13285 (UniProt - Evidence at protein level)
neXtProt	NX_Q13285
Antibodypedia	NR5A1 antibodies

PROTEIN BROWSER

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ENST00000373587		ENST00000373588		ENST00000455734		ENST00000620110

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
NR5A1-001	ENSP00000362690 ENST00000373588	Q13285 Show all » « Hide Q13285 [Direct mapping] Steroidogenic factor 1 F1D8R8 [Target identity:100%; Query identity:100%] Steroidogenic factor 1 nuclear receptor {ECO:0000313\|EMBL:ADZ17367.1} Q5T6F6 [Target identity:38%; Query identity:100%] Steroidogenic factor 1 {ECO:0000313\|Ensembl:ENSP00000393245} Q6QGY2 [Target identity:17%; Query identity:100%] Nuclear receptor AdBP4 {ECO:0000313\|EMBL:AAS48621.1} Q9H3V4 [Target identity:7%; Query identity:100%] Ad4BP {ECO:0000313\|EMBL:BAB18655.1}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014)	Show » « Hide GO:0001553 [luteinization] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007267 [cell-cell signaling] GO:0007538 [primary sex determination] GO:0008270 [zinc ion binding] GO:0008584 [male gonad development] GO:0008585 [female gonad development] GO:0009888 [tissue development] GO:0010259 [multicellular organismal aging] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0022414 [reproductive process] GO:0030154 [cell differentiation] GO:0030325 [adrenal gland development] GO:0030522 [intracellular receptor signaling pathway] GO:0042445 [hormone metabolic process] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050810 [regulation of steroid biosynthetic process] GO:0051457 [maintenance of protein location in nucleus] GO:2000020 [positive regulation of male gonad development] GO:2000195 [negative regulation of female gonad development]	461	51.6	No
NR5A1-002	ENSP00000362689 ENST00000373587	Q5T6F7 Show all » « Hide Q5T6F7 [Target identity:100%; Query identity:100%] Steroidogenic factor 1 {ECO:0000313\|Ensembl:ENSP00000362689}	Show » « Hide Nuclear receptors Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043401 [steroid hormone mediated signaling pathway]	245	28	No
NR5A1-003	ENSP00000393245 ENST00000455734	Q5T6F6 Show all » « Hide Q5T6F6 [Target identity:99%; Query identity:100%] Steroidogenic factor 1 {ECO:0000313\|Ensembl:ENSP00000393245} Q6QGY2 [Target identity:45%; Query identity:100%] Nuclear receptor AdBP4 {ECO:0000313\|EMBL:AAS48621.1} Q9H3V4 [Target identity:19%; Query identity:100%] Ad4BP {ECO:0000313\|EMBL:BAB18655.1}	Show » « Hide Nuclear receptors Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding]	178	19.5	No
NR5A1-201	ENSP00000483309 ENST00000620110	F1DAM0 Show all » « Hide F1DAM0 [Target identity:100%; Query identity:100%] Steroidogenic factor 1 nuclear receptor {ECO:0000313\|EMBL:ADZ17391.1} Q5T6F6 [Target identity:42%; Query identity:100%] Steroidogenic factor 1 {ECO:0000313\|Ensembl:ENSP00000393245} Q6QGY2 [Target identity:19%; Query identity:100%] Nuclear receptor AdBP4 {ECO:0000313\|EMBL:AAS48621.1} Q9H3V4 [Target identity:8%; Query identity:100%] Ad4BP {ECO:0000313\|EMBL:BAB18655.1}	Show » « Hide Nuclear receptors Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding]	421	47.1	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx