Tissue expression of SERPINE2 - Summary

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SERPINE2

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS

GENE/PROTEIN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	SERPINE2
Gene description	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Tissue enriched (placenta)
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability	Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW ? »
Protein expression data is shown for each of the 44 tissues. Color-coding is based on 13 tissue groups, each consisting of tissues with common functional features. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation. For genes with available protein data for which a knowledge-based annotation could not be performed, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Tissue enriched (placenta)

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	SERPINE2 (HGNC Symbol)
Synonyms	GDN, nexin, PI7, PN1, PNI
Description	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Chromosome	2
Cytoband	q36.1
Chromosome location (bp)	223975112 - 224039319
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135919 (version 78.38)
Entrez gene	5270
UniProt	P07093 (UniProt - Evidence at protein level)
neXtProt	NX_P07093
Antibodypedia	SERPINE2 antibodies

PROTEIN BROWSER

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ENST00000258405		ENST00000409304		ENST00000409840		ENST00000423446		ENST00000432738		ENST00000447280		ENST00000454956

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
SERPINE2-001	ENSP00000258405 ENST00000258405	P07093 Show all » « Hide P07093 [Direct mapping] Glia-derived nexin A0A024R451 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform CRA_a {ECO:0000313\|EMBL:EAW70822.1} C9JN98 [Target identity:69%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000408452} C9K031 [Target identity:21%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000399655} C9JRK5 [Target identity:10%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000394518}	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005539 [glycosaminoglycan binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0008201 [heparin binding] GO:0010757 [negative regulation of plasminogen activation] GO:0010951 [negative regulation of endopeptidase activity] GO:0010955 [negative regulation of protein processing] GO:0030195 [negative regulation of blood coagulation] GO:0030334 [regulation of cell migration] GO:0031012 [extracellular matrix] GO:0031091 [platelet alpha granule] GO:0031232 [extrinsic component of external side of plasma membrane] GO:0031594 [neuromuscular junction] GO:0031982 [vesicle] GO:0045861 [negative regulation of proteolysis] GO:0048711 [positive regulation of astrocyte differentiation] GO:0090331 [negative regulation of platelet aggregation]	398	44	Yes
SERPINE2-002	ENSP00000386412 ENST00000409304	P07093 Show all » « Hide P07093 [Direct mapping] Glia-derived nexin A0A024R498 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform CRA_b {ECO:0000313\|EMBL:EAW70824.1} B4DMR3 [Target identity:84%; Query identity:100%] cDNA FLJ51896, highly similar to Glia-derived nexin {ECO:0000313\|EMBL:BAG59975.1} C9JN98 [Target identity:69%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000408452} C9K031 [Target identity:21%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000399655} C9JRK5 [Target identity:10%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000394518}	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005539 [glycosaminoglycan binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0008201 [heparin binding] GO:0010757 [negative regulation of plasminogen activation] GO:0010951 [negative regulation of endopeptidase activity] GO:0010955 [negative regulation of protein processing] GO:0030195 [negative regulation of blood coagulation] GO:0030334 [regulation of cell migration] GO:0031012 [extracellular matrix] GO:0031091 [platelet alpha granule] GO:0031232 [extrinsic component of external side of plasma membrane] GO:0031594 [neuromuscular junction] GO:0031982 [vesicle] GO:0045861 [negative regulation of proteolysis] GO:0048711 [positive regulation of astrocyte differentiation] GO:0090331 [negative regulation of platelet aggregation]	397	44	Yes
SERPINE2-003	ENSP00000386969 ENST00000409840	P07093 Show all » « Hide P07093 [Direct mapping] Glia-derived nexin A0A024R498 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform CRA_b {ECO:0000313\|EMBL:EAW70824.1} B4DMR3 [Target identity:84%; Query identity:100%] cDNA FLJ51896, highly similar to Glia-derived nexin {ECO:0000313\|EMBL:BAG59975.1} C9JN98 [Target identity:69%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000408452} C9K031 [Target identity:21%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000399655} C9JRK5 [Target identity:10%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000394518}	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005539 [glycosaminoglycan binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0008201 [heparin binding] GO:0010757 [negative regulation of plasminogen activation] GO:0010951 [negative regulation of endopeptidase activity] GO:0010955 [negative regulation of protein processing] GO:0030195 [negative regulation of blood coagulation] GO:0030334 [regulation of cell migration] GO:0031012 [extracellular matrix] GO:0031091 [platelet alpha granule] GO:0031232 [extrinsic component of external side of plasma membrane] GO:0031594 [neuromuscular junction] GO:0031982 [vesicle] GO:0045861 [negative regulation of proteolysis] GO:0048711 [positive regulation of astrocyte differentiation] GO:0090331 [negative regulation of platelet aggregation]	397	44	Yes
SERPINE2-005	ENSP00000415786 ENST00000447280	P07093 Show all » « Hide P07093 [Direct mapping] Glia-derived nexin A0A024R498 [Target identity:97%; Query identity:100%] Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 2, isoform CRA_b {ECO:0000313\|EMBL:EAW70824.1} B4DMR3 [Target identity:81%; Query identity:100%] cDNA FLJ51896, highly similar to Glia-derived nexin {ECO:0000313\|EMBL:BAG59975.1} C9JN98 [Target identity:67%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000408452} C9K031 [Target identity:21%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000399655} C9JRK5 [Target identity:10%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000394518}	Show » « Hide SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005539 [glycosaminoglycan binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0008285 [negative regulation of cell proliferation] GO:0009611 [response to wounding] GO:0010466 [negative regulation of peptidase activity] GO:0010544 [negative regulation of platelet activation] GO:0010757 [negative regulation of plasminogen activation] GO:0010766 [negative regulation of sodium ion transport] GO:0010951 [negative regulation of endopeptidase activity] GO:0010955 [negative regulation of protein processing] GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling] GO:0021683 [cerebellar granular layer morphogenesis] GO:0030195 [negative regulation of blood coagulation] GO:0030308 [negative regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0031012 [extracellular matrix] GO:0031091 [platelet alpha granule] GO:0031232 [extrinsic component of external side of plasma membrane] GO:0031594 [neuromuscular junction] GO:0031982 [vesicle] GO:0032940 [secretion by cell] GO:0033363 [secretory granule organization] GO:0042177 [negative regulation of protein catabolic process] GO:0042628 [mating plug formation] GO:0045861 [negative regulation of proteolysis] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0048505 [regulation of timing of cell differentiation] GO:0048711 [positive regulation of astrocyte differentiation] GO:0050974 [detection of mechanical stimulus involved in sensory perception] GO:0051966 [regulation of synaptic transmission, glutamatergic] GO:0060291 [long-term synaptic potentiation] GO:0060384 [innervation] GO:0061108 [seminal vesicle epithelium development] GO:0090331 [negative regulation of platelet aggregation]	409	45.3	Yes
SERPINE2-007	ENSP00000399655 ENST00000454956	C9K031 Show all » « Hide C9K031 [Target identity:98%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000399655} C9JRK5 [Target identity:48%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000394518}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005615 [extracellular space]	87	9.5	Yes
SERPINE2-008	ENSP00000408452 ENST00000432738	C9JN98 Show all » « Hide C9JN98 [Target identity:99%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000408452} C9K031 [Target identity:31%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000399655} C9JRK5 [Target identity:15%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000394518}	Show » « Hide MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005615 [extracellular space]	276	30.5	Yes
SERPINE2-009	ENSP00000394518 ENST00000423446	C9JRK5 Show all » « Hide C9JRK5 [Target identity:100%; Query identity:100%] Glia-derived nexin {ECO:0000313\|Ensembl:ENSP00000394518}	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005615 [extracellular space]	42	4.7	Yes

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx