GLUL

GENE INFORMATION

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Gene name

GLUL (HGNC Symbol)

Synonyms

GLNS

Description

Glutamate-ammonia ligase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Chromosome

1

Cytoband

q25.3

Chromosome location (bp)

182381704 - 182392206

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135821 (version 78.38)

Entrez gene

2752

UniProt

P15104 (UniProt - Evidence at protein level)

neXtProt

NX_P15104

Antibodypedia

GLUL antibodies
 

PROTEIN VIEW

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GLUL-001
 
GLUL-002
 
GLUL-201
 
GLUL-202
 
GLUL-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GLUL-001 ENSP00000356537
ENST00000331872
P15104
Show all »
Show » Show » 373 42.1 No 0
GLUL-002 ENSP00000344958
ENST00000339526
P15104
Show all »
Show » Show » 373 42.1 No 0
GLUL-201 ENSP00000307900
ENST00000311223
P15104
Show all »
Show » Show » 373 42.1 No 0
GLUL-202 ENSP00000398320
ENST00000417584
P15104
Show all »
Show » Show » 373 42.1 No 0
GLUL-203 ENSP00000481855
ENST00000621524
Show » Show » 233 26.4 No 0