Tissue expression of MDM2 - Summary - The Human Protein Atlas

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MDM2

TISSUE

SUBCELL

CELL LINE

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN ANTIBODY/ANTIGEN


Dictionary

GENERAL INFORMATION ? »
Protein class Protein class the gene product belongs to according to selected gene lists. List of protein classes. Predicted localization Protein localization predicted from several bioinformatic algorithms. More info... Number of transcripts Number of protein-coding transcribed from this gene as defined by Ensembl.
Gene name	MDM2
Gene description	MDM2 proto-oncogene, E3 ubiquitin protein ligase
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	21
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY ? »
Data reliability description Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Currently, not all genes have been analyzed by knowledge-based annotation, indicated by "Pending RNA-based expert annotation", when applicable. Data reliability Data reliability score (score description), divided into supportive (premium) or uncertain (not premium), is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.
Data reliability description	Pending RNA-based expert annotation.
Data reliability	Supportive based on 2 antibodies. CAB000086 , CAB016303
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Lateral ventricle

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

N/A

Female tissues

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW

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Organ

Expression

RNA EXPRESSION OVERVIEW

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HPA dataset

RNA tissue category:

Expressed in all

Organ

Expression

GTEx dataset

RNA tissue category:

Expressed in all

Organ

Expression

GENE INFORMATION ? »
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	MDM2 (HGNC Symbol)
Synonyms	HDM2, MGC5370
Description	MDM2 proto-oncogene, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Chromosome	12
Cytoband	q15
Chromosome location (bp)	68808172 - 68850686
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135679 (version 78.38)
Entrez gene	4193
UniProt	Q00987 (UniProt - Evidence at protein level)
neXtProt	NX_Q00987
Antibodypedia	MDM2 antibodies

PROTEIN BROWSER

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ENST00000258148		ENST00000258149		ENST00000299252		ENST00000348801		ENST00000350057		ENST00000356290		ENST00000360430		ENST00000393410		ENST00000393412		ENST00000393413		ENST00000393415		ENST00000393416		ENST00000428863		ENST00000462284		ENST00000478070		ENST00000517852		ENST00000523991		ENST00000539479		ENST00000543323		ENST00000544561		ENST00000545204

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
MDM2-001	ENSP00000258149 ENST00000258149	Q00987 Show all » « Hide Q00987 [Direct mapping] E3 ubiquitin-protein ligase Mdm2 A8WFP2 [Target identity:98%; Query identity:100%] MDM2 protein {ECO:0000313\|EMBL:AAI52385.1} A7UKY0 [Target identity:51%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000444430}; Mdm2 {ECO:0000313\|EMBL:ABT17086.1} Q546E6 [Target identity:36%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007089 [traversing start control point of mitotic cell cycle] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009636 [response to toxic substance] GO:0009743 [response to carbohydrate] GO:0010039 [response to iron ion] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010955 [negative regulation of protein processing] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016604 [nuclear body] GO:0016874 [ligase activity] GO:0018205 [peptidyl-lysine modification] GO:0019899 [enzyme binding] GO:0030163 [protein catabolic process] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034504 [protein localization to nucleus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042176 [regulation of protein catabolic process] GO:0042220 [response to cocaine] GO:0042493 [response to drug] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0042975 [peroxisome proliferator activated receptor binding] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043234 [protein complex] GO:0043278 [response to morphine] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045087 [innate immune response] GO:0045184 [establishment of protein localization] GO:0045202 [synapse] GO:0045472 [response to ether] GO:0045787 [positive regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046677 [response to antibiotic] GO:0046827 [positive regulation of protein export from nucleus] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048545 [response to steroid hormone] GO:0070301 [cellular response to hydrogen peroxide] GO:0071157 [negative regulation of cell cycle arrest] GO:0071229 [cellular response to acid] GO:0071236 [cellular response to antibiotic] GO:0071301 [cellular response to vitamin B1] GO:0071310 [cellular response to organic substance] GO:0071312 [cellular response to alkaloid] GO:0071363 [cellular response to growth factor stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071391 [cellular response to estrogen stimulus] GO:0071407 [cellular response to organic cyclic compound] GO:0071456 [cellular response to hypoxia] GO:0071494 [cellular response to UV-C] GO:0097110 [scaffold protein binding]	497	56	No
MDM2-003	ENSP00000258148 ENST00000258148	G3XA89 Show all » « Hide G3XA89 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000258148}; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (Mouse), isoform CRA_g {ECO:0000313\|EMBL:EAW97207.1} Q546E6 [Target identity:40%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	442	50	No
MDM2-004	ENSP00000377062 ENST00000393410	Q9H4C5 Show all » « Hide Q9H4C5 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000377062}; p53-binding protein {ECO:0000313\|EMBL:CAC07809.1} Q546E6 [Target identity:74%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	243	27.3	No
MDM2-006	ENSP00000299252 ENST00000299252	Q00987 Show all » « Hide Q00987 [Direct mapping] E3 ubiquitin-protein ligase Mdm2 Q546E6 [Target identity:56%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1} E7EMW5 [Target identity:44%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000427828}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016604 [nuclear body] GO:0016874 [ligase activity] GO:0018205 [peptidyl-lysine modification] GO:0019899 [enzyme binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034504 [protein localization to nucleus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042176 [regulation of protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045087 [innate immune response] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046677 [response to antibiotic] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia]	321	36	No
MDM2-008	ENSP00000353611 ENST00000360430	Q00987 Show all » « Hide Q00987 [Direct mapping] E3 ubiquitin-protein ligase Mdm2 Q546E6 [Target identity:61%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016604 [nuclear body] GO:0016874 [ligase activity] GO:0018205 [peptidyl-lysine modification] GO:0019899 [enzyme binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034504 [protein localization to nucleus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042176 [regulation of protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045087 [innate immune response] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046677 [response to antibiotic] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia]	296	33.1	No
MDM2-009	ENSP00000335096 ENST00000348801	Q00987 Show all » « Hide Q00987 [Direct mapping] E3 ubiquitin-protein ligase Mdm2 Q546E6 [Target identity:68%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016604 [nuclear body] GO:0016874 [ligase activity] GO:0018205 [peptidyl-lysine modification] GO:0019899 [enzyme binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034504 [protein localization to nucleus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042176 [regulation of protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045087 [innate immune response] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046677 [response to antibiotic] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia]	265	29.7	No
MDM2-011	ENSP00000430906 ENST00000478070	E5RHE2 Show all » « Hide E5RHE2 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000430906}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)		49	5.1	No
MDM2-012	ENSP00000444430 ENST00000539479	A7UKY0 Show all » « Hide A7UKY0 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000444430}; Mdm2 {ECO:0000313\|EMBL:ABT17086.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	257	28.8	No
MDM2-013	ENSP00000377068 ENST00000393416	E7EPE2 Show all » « Hide E7EPE2 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000377068}	Show » « Hide SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	229	26.1	No
MDM2-016	ENSP00000427828 ENST00000523991	E7EMW5 Show all » « Hide E7EMW5 [Target identity:99%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000427828}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	144	16	No
MDM2-019	ENSP00000430257 ENST00000517852	Q9H4C3 Show all » « Hide Q9H4C3 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000430257}; p53 binding protein {ECO:0000313\|EMBL:CAC07811.1} I6TMT6 [Target identity:100%; Query identity:97%] HDM2 transcript variant MYO-11 {ECO:0000313\|EMBL:AFM80531.1}; HDM2 transcript variant MYO-12 {ECO:0000313\|EMBL:AFM80532.1} I6SST1 [Target identity:91%; Query identity:100%] HDM2 transcript variant MYO-9 {ECO:0000313\|EMBL:AFM80530.1} I6TZT0 [Target identity:89%; Query identity:100%] HDM2 transcript variant MYO-8 {ECO:0000313\|EMBL:AFM80529.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	130	14.5	No
MDM2-022	ENSP00000377067 ENST00000393415	A7UKX8 Show all » « Hide A7UKX8 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000377067}; Mdm2 {ECO:0000313\|EMBL:ABT17084.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	256	28.7	No
MDM2-023	ENSP00000439238 ENST00000543323	A7UKX7 Show all » « Hide A7UKX7 [Target identity:100%; Query identity:100%] Mdm2 {ECO:0000313\|EMBL:ABT17083.1} F6RKA8 [Target identity:99%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000439238}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0016567 [protein ubiquitination]	118	13.1	No
MDM2-024	ENSP00000444597 ENST00000545204	F5GZB0 Show all » « Hide F5GZB0 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000444597}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)		51	5.5	No
MDM2-026	ENSP00000441841 ENST00000544561	F5GWH7 Show all » « Hide F5GWH7 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000441841}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0016567 [protein ubiquitination]	70	7.8	No
MDM2-032	ENSP00000377065 ENST00000393413	Q00987 Show all » « Hide Q00987 [Direct mapping] E3 ubiquitin-protein ligase Mdm2 Q546E6 [Target identity:83%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016604 [nuclear body] GO:0016874 [ligase activity] GO:0018205 [peptidyl-lysine modification] GO:0019899 [enzyme binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034504 [protein localization to nucleus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042176 [regulation of protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045087 [innate immune response] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046677 [response to antibiotic] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia]	218	24.5	No
MDM2-033	ENSP00000266624 ENST00000350057	J3KN53 Show all » « Hide J3KN53 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000266624} Q546E6 [Target identity:38%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	466	52.4	No
MDM2-201	ENSP00000348637 ENST00000356290	Q00987 Show all » « Hide Q00987 [Direct mapping] E3 ubiquitin-protein ligase Mdm2 Q546E6 [Target identity:56%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1} E7EMW5 [Target identity:44%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000427828}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016604 [nuclear body] GO:0016874 [ligase activity] GO:0018205 [peptidyl-lysine modification] GO:0019899 [enzyme binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034504 [protein localization to nucleus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042176 [regulation of protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045087 [innate immune response] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046677 [response to antibiotic] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia]	321	36	No
MDM2-202	ENSP00000377064 ENST00000393412	Q9H4C5 Show all » « Hide Q9H4C5 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000377062}; p53-binding protein {ECO:0000313\|EMBL:CAC07809.1} Q546E6 [Target identity:74%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	243	27.3	No
MDM2-203	ENSP00000410694 ENST00000428863	Q8TE47 Show all » « Hide Q8TE47 [Target identity:100%; Query identity:100%] MDM2 isoform KB9 protein {ECO:0000313\|EMBL:CAD23251.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	243	27.3	No
MDM2-204	ENSP00000417281 ENST00000462284	J3KN53 Show all » « Hide J3KN53 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000266624} Q546E6 [Target identity:38%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	466	52.4	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.

Protein class

Predicted localization

Number of transcripts

RNA tissue category

Protein evidence

Protein localization

Data reliability description

Data reliability

RNA expression (FPKM)

Protein expression (score)

HPA dataset

RNA tissue category HPA

GTEx dataset

RNA tissue category GTEx