MDM2 - Gene info - The Human Protein Atlas

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MDM2

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	MDM2 (HGNC Symbol)
Synonyms	HDM2, MGC5370
Description	MDM2 proto-oncogene, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Chromosome	12
Cytoband	q15
Chromosome location (bp)	68808172 - 68850686
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135679 (version 78.38)
Entrez gene	4193
UniProt	Q00987 (UniProt - Evidence at protein level)
neXtProt	NX_Q00987
Antibodypedia	MDM2 antibodies

PROTEIN VIEW

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MDM2-001		MDM2-003		MDM2-004		MDM2-006		MDM2-008		MDM2-009		MDM2-011		MDM2-012		MDM2-013		MDM2-016		MDM2-019		MDM2-022		MDM2-023		MDM2-024		MDM2-026		MDM2-032		MDM2-033		MDM2-201		MDM2-202		MDM2-203		MDM2-204

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
MDM2-001	ENSP00000258149 ENST00000258149	Q00987 Show all » « Hide Q00987 [Direct mapping] E3 ubiquitin-protein ligase Mdm2 A8WFP2 [Target identity:98%; Query identity:100%] MDM2 protein {ECO:0000313\|EMBL:AAI52385.1} A7UKY0 [Target identity:51%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000444430}; Mdm2 {ECO:0000313\|EMBL:ABT17086.1} Q546E6 [Target identity:36%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007089 [traversing start control point of mitotic cell cycle] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009636 [response to toxic substance] GO:0009743 [response to carbohydrate] GO:0010039 [response to iron ion] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010955 [negative regulation of protein processing] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016604 [nuclear body] GO:0016874 [ligase activity] GO:0018205 [peptidyl-lysine modification] GO:0019899 [enzyme binding] GO:0030163 [protein catabolic process] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034504 [protein localization to nucleus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042176 [regulation of protein catabolic process] GO:0042220 [response to cocaine] GO:0042493 [response to drug] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0042975 [peroxisome proliferator activated receptor binding] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043234 [protein complex] GO:0043278 [response to morphine] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045087 [innate immune response] GO:0045184 [establishment of protein localization] GO:0045202 [synapse] GO:0045472 [response to ether] GO:0045787 [positive regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046677 [response to antibiotic] GO:0046827 [positive regulation of protein export from nucleus] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048545 [response to steroid hormone] GO:0070301 [cellular response to hydrogen peroxide] GO:0071157 [negative regulation of cell cycle arrest] GO:0071229 [cellular response to acid] GO:0071236 [cellular response to antibiotic] GO:0071301 [cellular response to vitamin B1] GO:0071310 [cellular response to organic substance] GO:0071312 [cellular response to alkaloid] GO:0071363 [cellular response to growth factor stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071391 [cellular response to estrogen stimulus] GO:0071407 [cellular response to organic cyclic compound] GO:0071456 [cellular response to hypoxia] GO:0071494 [cellular response to UV-C] GO:0097110 [scaffold protein binding]	497	56	No
MDM2-003	ENSP00000258148 ENST00000258148	G3XA89 Show all » « Hide G3XA89 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000258148}; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (Mouse), isoform CRA_g {ECO:0000313\|EMBL:EAW97207.1} Q546E6 [Target identity:40%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	442	50	No
MDM2-004	ENSP00000377062 ENST00000393410	Q9H4C5 Show all » « Hide Q9H4C5 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000377062}; p53-binding protein {ECO:0000313\|EMBL:CAC07809.1} Q546E6 [Target identity:74%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	243	27.3	No
MDM2-006	ENSP00000299252 ENST00000299252	Q00987 Show all » « Hide Q00987 [Direct mapping] E3 ubiquitin-protein ligase Mdm2 Q546E6 [Target identity:56%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1} E7EMW5 [Target identity:44%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000427828}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016604 [nuclear body] GO:0016874 [ligase activity] GO:0018205 [peptidyl-lysine modification] GO:0019899 [enzyme binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034504 [protein localization to nucleus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042176 [regulation of protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045087 [innate immune response] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046677 [response to antibiotic] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia]	321	36	No
MDM2-008	ENSP00000353611 ENST00000360430	Q00987 Show all » « Hide Q00987 [Direct mapping] E3 ubiquitin-protein ligase Mdm2 Q546E6 [Target identity:61%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016604 [nuclear body] GO:0016874 [ligase activity] GO:0018205 [peptidyl-lysine modification] GO:0019899 [enzyme binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034504 [protein localization to nucleus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042176 [regulation of protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045087 [innate immune response] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046677 [response to antibiotic] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia]	296	33.1	No
MDM2-009	ENSP00000335096 ENST00000348801	Q00987 Show all » « Hide Q00987 [Direct mapping] E3 ubiquitin-protein ligase Mdm2 Q546E6 [Target identity:68%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016604 [nuclear body] GO:0016874 [ligase activity] GO:0018205 [peptidyl-lysine modification] GO:0019899 [enzyme binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034504 [protein localization to nucleus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042176 [regulation of protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045087 [innate immune response] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046677 [response to antibiotic] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia]	265	29.7	No
MDM2-011	ENSP00000430906 ENST00000478070	E5RHE2 Show all » « Hide E5RHE2 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000430906}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)		49	5.1	No
MDM2-012	ENSP00000444430 ENST00000539479	A7UKY0 Show all » « Hide A7UKY0 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000444430}; Mdm2 {ECO:0000313\|EMBL:ABT17086.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	257	28.8	No
MDM2-013	ENSP00000377068 ENST00000393416	E7EPE2 Show all » « Hide E7EPE2 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000377068}	Show » « Hide SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	229	26.1	No
MDM2-016	ENSP00000427828 ENST00000523991	E7EMW5 Show all » « Hide E7EMW5 [Target identity:99%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000427828}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	144	16	No
MDM2-019	ENSP00000430257 ENST00000517852	Q9H4C3 Show all » « Hide Q9H4C3 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000430257}; p53 binding protein {ECO:0000313\|EMBL:CAC07811.1} I6TMT6 [Target identity:100%; Query identity:97%] HDM2 transcript variant MYO-11 {ECO:0000313\|EMBL:AFM80531.1}; HDM2 transcript variant MYO-12 {ECO:0000313\|EMBL:AFM80532.1} I6SST1 [Target identity:91%; Query identity:100%] HDM2 transcript variant MYO-9 {ECO:0000313\|EMBL:AFM80530.1} I6TZT0 [Target identity:89%; Query identity:100%] HDM2 transcript variant MYO-8 {ECO:0000313\|EMBL:AFM80529.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	130	14.5	No
MDM2-022	ENSP00000377067 ENST00000393415	A7UKX8 Show all » « Hide A7UKX8 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000377067}; Mdm2 {ECO:0000313\|EMBL:ABT17084.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	256	28.7	No
MDM2-023	ENSP00000439238 ENST00000543323	A7UKX7 Show all » « Hide A7UKX7 [Target identity:100%; Query identity:100%] Mdm2 {ECO:0000313\|EMBL:ABT17083.1} F6RKA8 [Target identity:99%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000439238}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0016567 [protein ubiquitination]	118	13.1	No
MDM2-024	ENSP00000444597 ENST00000545204	F5GZB0 Show all » « Hide F5GZB0 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000444597}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)		51	5.5	No
MDM2-026	ENSP00000441841 ENST00000544561	F5GWH7 Show all » « Hide F5GWH7 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000441841}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0016567 [protein ubiquitination]	70	7.8	No
MDM2-032	ENSP00000377065 ENST00000393413	Q00987 Show all » « Hide Q00987 [Direct mapping] E3 ubiquitin-protein ligase Mdm2 Q546E6 [Target identity:83%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016604 [nuclear body] GO:0016874 [ligase activity] GO:0018205 [peptidyl-lysine modification] GO:0019899 [enzyme binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034504 [protein localization to nucleus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042176 [regulation of protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045087 [innate immune response] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046677 [response to antibiotic] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia]	218	24.5	No
MDM2-033	ENSP00000266624 ENST00000350057	J3KN53 Show all » « Hide J3KN53 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000266624} Q546E6 [Target identity:38%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	466	52.4	No
MDM2-201	ENSP00000348637 ENST00000356290	Q00987 Show all » « Hide Q00987 [Direct mapping] E3 ubiquitin-protein ligase Mdm2 Q546E6 [Target identity:56%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1} E7EMW5 [Target identity:44%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000427828}	Show » « Hide Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016604 [nuclear body] GO:0016874 [ligase activity] GO:0018205 [peptidyl-lysine modification] GO:0019899 [enzyme binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034504 [protein localization to nucleus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042176 [regulation of protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045087 [innate immune response] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046677 [response to antibiotic] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia]	321	36	No
MDM2-202	ENSP00000377064 ENST00000393412	Q9H4C5 Show all » « Hide Q9H4C5 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000377062}; p53-binding protein {ECO:0000313\|EMBL:CAC07809.1} Q546E6 [Target identity:74%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	243	27.3	No
MDM2-203	ENSP00000410694 ENST00000428863	Q8TE47 Show all » « Hide Q8TE47 [Target identity:100%; Query identity:100%] MDM2 isoform KB9 protein {ECO:0000313\|EMBL:CAD23251.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	243	27.3	No
MDM2-204	ENSP00000417281 ENST00000462284	J3KN53 Show all » « Hide J3KN53 [Target identity:100%; Query identity:100%] E3 ubiquitin-protein ligase Mdm2 {ECO:0000313\|Ensembl:ENSP00000266624} Q546E6 [Target identity:38%; Query identity:100%] P53-binding protein {ECO:0000313\|EMBL:CAD57167.1}	Show » « Hide Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]	466	52.4	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.