MYBPC3

GENE INFORMATION

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Gene name

MYBPC3 (HGNC Symbol)

Synonyms

CMH4, FHC, MYBP-C

Description

Myosin binding protein C, cardiac (HGNC Symbol)

Entrez gene summary

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p11.2

Chromosome location (bp)

47331397 - 47352702

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134571 (version 78.38)

Entrez gene

4607

UniProt

Q14896 (UniProt - Evidence at protein level)

neXtProt

NX_Q14896

Antibodypedia

MYBPC3 antibodies
 

PROTEIN VIEW

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MYBPC3-001
 
MYBPC3-201
 
MYBPC3-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MYBPC3-001 ENSP00000442795
ENST00000545968
Q14896
Show all »
Show » Show » 1274 140.8 No 0
MYBPC3-201 ENSP00000256993
ENST00000256993
D3DQR5
Show all »
Show » Show » 1274 140.7 No 0
MYBPC3-202 ENSP00000382193
ENST00000399249
A8MXZ9
Show all »
Show » Show » 1274 140.7 No 0