ARNTL

GENERAL INFORMATION

? »

Gene name

ARNTL

Gene description

Aryl hydrocarbon receptor nuclear translocator-like

Protein class

Predicted intracellular proteins
Predicted secreted proteins
Transcription factors

Predicted localization

Intracellular,Secreted

Number of transcripts

14
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed moderate nuclear positivity. Salivary gland, exocrine glandular cells, adrenal, hematopoietic cells, cardiac myocytes and glial cells in hippocampus showed strong positivity. Purkinje cells was negative.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 1 antibody.
CAB045962
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

ARNTL (HGNC Symbol)

Synonyms

bHLHe5, BMAL1, JAP3, MOP3, PASD3

Description

Aryl hydrocarbon receptor nuclear translocator-like (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Chromosome

11

Cytoband

p15.3

Chromosome location (bp)

13276652 - 13387266

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000133794 (version 78.38)

Entrez gene

406

UniProt

O00327 (UniProt - Evidence at protein level)

neXtProt

NX_O00327

Antibodypedia

ARNTL antibodies


PROTEIN BROWSER

? »
 
 
 « 
 
ENST00000389707
 
ENST00000401424
 
ENST00000403290
 
ENST00000403482
 
ENST00000403510
 
ENST00000482049
 
ENST00000527998
 
ENST00000529050
 
ENST00000529388
 
ENST00000529825
 
ENST00000530357
 
ENST00000531665
 
ENST00000533520
 
ENST00000534544
 
 » 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARNTL-001 ENSP00000374357
ENST00000389707
O00327
Show all »
Show » Show » 625 68.7 No 0
ARNTL-002 ENSP00000385581
ENST00000403510
O00327
Show all »
Show » Show » 582 64.1 No 0
ARNTL-003 ENSP00000385915
ENST00000401424
O00327
Show all »
Show » Show » 583 64.2 No 0
ARNTL-004 ENSP00000384517
ENST00000403290
O00327
Show all »
Show » Show » 626 68.8 No 0
ARNTL-005 ENSP00000385897
ENST00000403482
O00327
Show all »
Show » Show » 624 68.8 Yes 0
ARNTL-008 ENSP00000436721
ENST00000482049
E9PI92
Show all »
Show » Show » 72 8.4 No 0
ARNTL-011 ENSP00000434781
ENST00000531665
E9PNI4
Show all »
Show » 60 6.6 No 0
ARNTL-015 ENSP00000431566
ENST00000534544
E9PKN1
Show all »
Show » 59 6.4 No 0
ARNTL-016 ENSP00000434044
ENST00000529050
E9PSD2
Show all »
Show » 23 2.5 No 0
ARNTL-017 ENSP00000434263
ENST00000529825
E9PRB1
Show all »
Show » Show » 46 5.6 No 0
ARNTL-018 ENSP00000436313
ENST00000530357
E9PPV4
Show all »
Show » Show » 141 16.2 No 0
ARNTL-019 ENSP00000433540
ENST00000527998
E9PKG7
Show all »
Show » 76 8.4 No 0
ARNTL-020 ENSP00000431488
ENST00000533520
E9PL54
Show all »
Show » Show » 101 11.4 No 0
ARNTL-022 ENSP00000433571
ENST00000529388
E9PKF0
Show all »
Show » Show » 135 15.2 No 0