KRAS

GENERAL INFORMATION

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Gene name

KRAS

Gene description

Kirsten rat sarcoma viral oncogene homolog

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and membranous expression in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Data reliability

Uncertain based on 1 antibody.
HPA049830
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

KRAS (HGNC Symbol)

Synonyms

KRAS1, KRAS2

Description

Kirsten rat sarcoma viral oncogene homolog (HGNC Symbol)

Entrez gene summary

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p12.1

Chromosome location (bp)

25204789 - 25250936

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000133703 (version 78.38)

Entrez gene

3845

UniProt

P01116 (UniProt - Evidence at protein level)

neXtProt

NX_P01116

Antibodypedia

KRAS antibodies


PROTEIN BROWSER

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ENST00000256078
 
ENST00000311936
 
ENST00000556131
 
ENST00000557334
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KRAS-001 ENSP00000308495
ENST00000311936
P01116
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Show » Show » 188 21.4 No 0
KRAS-002 ENSP00000451856
ENST00000556131
G3V4K2
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Show » Show » 43 4.7 No 0
KRAS-003 ENSP00000452512
ENST00000557334
G3V5T7
Show all »
Show » Show » 75 8.5 No 0
KRAS-004 ENSP00000256078
ENST00000256078
P01116
Show all »
Show » Show » 189 21.7 No 0