EPO

GENERAL INFORMATION

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Gene name

EPO

Gene description

Erythropoietin

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (liver)
GTEx:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein localization

Secreted protein mainly found in red blood cells, extracellular locations and a subset of renal cells.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA027572 , CAB010336
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (liver)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression



GENE INFORMATION

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Gene name

EPO (HGNC Symbol)

Synonyms

EP

Description

Erythropoietin (HGNC Symbol)

Entrez gene summary

This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q22.1

Chromosome location (bp)

100720800 - 100723700

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000130427 (version 78.38)

Entrez gene

2056

UniProt

P01588 (UniProt - Evidence at protein level)

neXtProt

NX_P01588

Antibodypedia

EPO antibodies


PROTEIN BROWSER

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ENST00000252723
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EPO-001 ENSP00000252723
ENST00000252723
P01588
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