PSMA1

GENERAL INFORMATION

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Gene name

PSMA1

Gene description

Proteasome (prosome, macropain) subunit, alpha type, 1

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic and nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA037646 , HPA043891 , CAB033765
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PSMA1 (HGNC Symbol)

Synonyms

HC2, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915, NU, PROS30

Description

Proteasome (prosome, macropain) subunit, alpha type, 1 (HGNC Symbol)

Entrez gene summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Chromosome

11

Cytoband

p15.2

Chromosome location (bp)

14504874 - 14643635

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129084 (version 78.38)

Entrez gene

5682

UniProt

P25786 (UniProt - Evidence at protein level)

neXtProt

NX_P25786

Antibodypedia

PSMA1 antibodies


PROTEIN BROWSER

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ENST00000396394
 
ENST00000418988
 
ENST00000530457
 
ENST00000532256
 
ENST00000533068
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMA1-001 ENSP00000379676
ENST00000396394
P25786
Show all »
Show » Show » 263 29.6 No 0
PSMA1-002 ENSP00000414359
ENST00000418988
P25786
Show all »
Show » Show » 269 30.2 No 0
PSMA1-004 ENSP00000441166
ENST00000530457
F5GX11
Show all »
Show » Show » 238 26.5 No 0
PSMA1-009 ENSP00000439724
ENST00000533068
Show » 14 1.4 No 0
PSMA1-010 ENSP00000439080
ENST00000532256
Show » 2 0.3 No 0