ATF4

GENERAL INFORMATION

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Gene name

ATF4

Gene description

Activating transcription factor 4

Protein class

Cytoskeleton related proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues displayed weak to moderate nuclear positivity. Glial cells showed strong nuclear staining while strong membranous staining was observed in trophoblastic cells. Neuronal cells and lymphoid tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB011596
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ATF4 (HGNC Symbol)

Synonyms

CREB-2, TAXREB67, TXREB

Description

Activating transcription factor 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

Chromosome

22

Cytoband

q13.1

Chromosome location (bp)

39519695 - 39522685

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128272 (version 78.38)

Entrez gene

468

UniProt

P18848 (UniProt - Evidence at protein level)

neXtProt

NX_P18848

Antibodypedia

ATF4 antibodies


PROTEIN BROWSER

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ENST00000337304
 
ENST00000396680
 
ENST00000404241
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATF4-001 ENSP00000384587
ENST00000404241
P18848
Show all »
Show » Show » 351 38.6 No 0
ATF4-002 ENSP00000336790
ENST00000337304
P18848
Show all »
Show » Show » 351 38.6 No 0
ATF4-201 ENSP00000379912
ENST00000396680
P18848
Show all »
Show » Show » 351 38.6 No 0