NR1D1

GENERAL INFORMATION

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Gene name

NR1D1

Gene description

Nuclear receptor subfamily 1, group D, member 1

Protein class

Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues showed weak to moderate cytoplasmic positivity. Strong staining was observed in prostate, fallopian tube, Leydig cells, epididymis, Purkinje cells and subsets of lymphoid cells.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA007935
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

NR1D1 (HGNC Symbol)

Synonyms

ear-1, hRev, Rev-ErbAalpha, THRA1, THRAL

Description

Nuclear receptor subfamily 1, group D, member 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Jan 2013]

Chromosome

17

Cytoband

q21.1

Chromosome location (bp)

40092787 - 40100725

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000126368 (version 78.38)

Entrez gene

9572

UniProt

P20393 (UniProt - Evidence at protein level)

neXtProt

NX_P20393

Antibodypedia

NR1D1 antibodies


PROTEIN BROWSER

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ENST00000246672
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NR1D1-001 ENSP00000246672
ENST00000246672
P20393
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