CCR7

GENERAL INFORMATION

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Gene name

CCR7

Gene description

Chemokine (C-C motif) receptor 7

Protein class

Cancer-related genes
CD markers
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (appendix, lymph node, spleen, tonsil)
GTEx:Group enriched (small intestine, spleen)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in subsets of inflammatory cells

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
CAB003796
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (appendix, lymph node, spleen, tonsil)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (small intestine, spleen)

Organ

Expression



GENE INFORMATION

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Gene name

CCR7 (HGNC Symbol)

Synonyms

BLR2, CD197, CDw197, CMKBR7, EBI1

Description

Chemokine (C-C motif) receptor 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Chromosome

17

Cytoband

q21.2

Chromosome location (bp)

40553769 - 40565472

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000126353 (version 78.38)

Entrez gene

1236

UniProt

P32248 (UniProt - Evidence at protein level)

neXtProt

NX_P32248

Antibodypedia

CCR7 antibodies


PROTEIN BROWSER

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ENST00000246657
 
ENST00000578085
 
ENST00000579344
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCR7-001 ENSP00000246657
ENST00000246657
P32248
Show all »
Show » Show » 378 42.9 Yes 7
CCR7-002 ENSP00000462631
ENST00000579344
J3KSS9
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Show » Show » 372 42.2 Yes 7
CCR7-003 ENSP00000463075
ENST00000578085
J3KTN5
Show all »
Show » Show » 199 22.6 No 5