IL1B

GENERAL INFORMATION

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Gene name

IL1B

Gene description

Interleukin 1, beta

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (bone marrow)
GTEx:Tissue enhanced (adipose tissue, lung, stomach)

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (bone marrow)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (adipose tissue, lung, stomach)

Organ

Expression



GENE INFORMATION

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Gene name

IL1B (HGNC Symbol)

Synonyms

IL-1B, IL1-BETA, IL1F2

Description

Interleukin 1, beta (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q14.1

Chromosome location (bp)

112829751 - 112836903

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125538 (version 78.38)

Entrez gene

3553

UniProt

P01584 (UniProt - Evidence at protein level)

neXtProt

NX_P01584

Antibodypedia

IL1B antibodies


PROTEIN BROWSER

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ENST00000263341
 
ENST00000416750
 
ENST00000418817
 
ENST00000432018
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL1B-001 ENSP00000263341
ENST00000263341
P01584
Show all »
Show » Show » 269 30.7 No 0
IL1B-003 ENSP00000407219
ENST00000418817
C9JWV2
Show all »
Show » Show » 143 16.4 No 0
IL1B-006 ENSP00000400854
ENST00000416750
C9JVK0
Show all »
Show » Show » 111 12.8 No 0
IL1B-007 ENSP00000409680
ENST00000432018
C9JSC2
Show all »
Show » Show » 125 14.3 No 0